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Increased level of serum prostaglandin-2 in early stage of esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
Prostaglandin-
2
(
PGE-
2
)
,
one
of
the
products
of
cyclooxygenase-
2
(
COX
-
2
)
induced
catalysis
,
may
play
a
critical
role
in
the
carcinogenesis
of
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
We
investigated
the
efficacy
of
using
serum
PGE-
2
concentration
as
a
biomarker
for
this
cancer
type
.
Prostaglandin-
2
levels
were
analyzed
in
the
serum
of
65
ESCC
patients
and
in
47
healthy
individuals
.
The
concentrations
of
cyclooxygenase-
2
(
COX
-
2
)
were
measured
in
tumor
tissues
and
normal
tissues
obtained
from
31
surgically
treated
ESCC
patients
.
Serum
PGE-
2
concentration
was
significantly
higher
in
ESCC
patients
than
in
control
patients
(
p
=
0
.
004
)
,
especially
in
the
early
stages
(
I
+
II
)
of
cancer
(
p
<
0
.
0001
)
.
We
observed
significant
inverse
relationships
between
serum
PGE-
2
levels
and
:
tumor
stage
,
primary
tumor
progression
,
lymph
and
distant
metastasis
.
The
COX
-
2
concentration
was
significantly
elevated
in
tumors
as
compared
to
normal
tissues
(
p
=
0
.
008
)
.
A
significant
correlation
between
serum
PGE-
2
and
tumor
COX
-
2
was
observed
(
rho
=
0
.
46
,
p
=
0
.
009
)
.
However
,
ROC
analysis
showed
that
serum
PGE-
2
may
be
a
weak
prognostic
factor
for
ESCC
.
Our
results
suggest
that
an
elevated
concentration
of
serum
PGE-
2
in
the
early
stages
of
cancer
may
possibly
be
associated
with
tumor
initiation
and
cancer
development
in
ESCC
.
The
exact
role
of
these
findings
in
early
detection
of
this
highly
lethal
cancer
requires
further
research
.
Diseases
Validation
Diseases presenting
"early detection"
symptom
22q11.2 deletion syndrome
acute rheumatic fever
adrenomyeloneuropathy
allergic bronchopulmonary aspergillosis
carcinoma of the gallbladder
child syndrome
cholangiocarcinoma
classical phenylketonuria
congenital diaphragmatic hernia
cowden syndrome
cystinuria
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal squamous cell carcinoma
fabry disease
homocystinuria without methylmalonic aciduria
inclusion body myositis
kallmann syndrome
krabbe disease
oral submucous fibrosis
papillon-lefèvre syndrome
phenylketonuria
pyomyositis
von hippel-lindau disease
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