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Increased level of serum prostaglandin-2 in early stage of esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
Prostaglandin-
2
(
PGE-
2
)
,
one
of
the
products
of
cyclooxygenase-
2
(
COX
-
2
)
induced
catalysis
,
may
play
a
critical
role
in
the
carcinogenesis
of
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
We
investigated
the
efficacy
of
using
serum
PGE-
2
concentration
as
a
biomarker
for
this
cancer
type
.
Prostaglandin-
2
levels
were
analyzed
in
the
serum
of
65
ESCC
patients
and
in
47
healthy
individuals
.
The
concentrations
of
cyclooxygenase-
2
(
COX
-
2
)
were
measured
in
tumor
tissues
and
normal
tissues
obtained
from
31
surgically
treated
ESCC
patients
.
Serum
PGE-
2
concentration
was
significantly
higher
in
ESCC
patients
than
in
control
patients
(
p
=
0
.
004
)
,
especially
in
the
early
stages
(
I
+
II
)
of
cancer
(
p
<
0
.
0001
)
.
We
observed
significant
inverse
relationships
between
serum
PGE-
2
levels
and
:
tumor
stage
,
primary
tumor
progression
,
lymph
and
distant
metastasis
.
The
COX
-
2
concentration
was
significantly
elevated
in
tumors
as
compared
to
normal
tissues
(
p
=
0
.
008
)
.
A
significant
correlation
between
serum
PGE-
2
and
tumor
COX
-
2
was
observed
(
rho
=
0
.
46
,
p
=
0
.
009
)
.
However
,
ROC
analysis
showed
that
serum
PGE-
2
may
be
a
weak
prognostic
factor
for
ESCC
.
Our
results
suggest
that
an
elevated
concentration
of
serum
PGE-
2
in
the
early
stages
of
cancer
may
possibly
be
associated
with
tumor
initiation
and
cancer
development
in
ESCC
.
The
exact
role
of
these
findings
in
early
detection
of
this
highly
lethal
cancer
requires
further
research
.
Diseases
Validation
Diseases presenting
"cancer development in escc"
symptom
esophageal squamous cell carcinoma
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