Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression.
[esophageal squamous cell carcinoma]
The
integrins
are
a
family
of
heterodimeric
transmembrane
signaling
receptors
that
mediate
the
adhesive
properties
of
epithelial
cells
affecting
cell
growth
and
differentiation
.
In
many
epithelial
malignancies
,
altered
integrin
expression
is
associated
with
tumor
progression
and
often
correlates
with
unfavorable
prognosis
.
However
,
only
few
studies
have
investigated
the
role
of
integrin
expression
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
Using
a
novel
quantifying
immunofluorescence-staining
assay
,
we
investigated
the
expression
of
the
integrins
α
2
β
1
,
α
3
β
1
,
α
6
β
1
,
and
α
6
β
4
in
primary
ESCC
of
36
patients
who
underwent
surgical
resection
.
Magnitude
and
distribution
of
expression
were
analyzed
in
primary
tumor
samples
and
autologous
esophageal
squamous
epithelium
.
The
persistence
of
the
physiologically
polarized
expression
of
the
subunits
α
6
,
β
1
,
and
β
4
in
the
tumor
tissue
was
significantly
associated
with
prolonged
relapse-free
survival
(
p
 
=
 
0
.
028
,
p
 
=
 
0
.
034
,
p
 
=
 
0
.
006
)
.
In
contrast
,
patients
with
reduced
focal
α
6
expression
at
the
tumor
invasion
front
shared
a
significantly
shortened
relapse-free
survival
compared
to
patients
with
strong
α
6
expression
at
their
stromal
surfaces
,
as
it
was
regularly
observed
in
normal
esophageal
epithelium
(
p
 
=
 
0
.
001
)
.
Multivariate
regression
analysis
identified
the
maintenance
of
strong
α
6
immunoreactivity
at
the
invasion
front
as
an
independent
prognostic
factor
for
increased
relapse-free
and
disease-
specific
survival
(
p
 
=
 
0
.
003
;
p
 
=
 
0
.
003
)
.
Our
findings
suggest
that
alterations
in
both
pattern
and
magnitude
of
integrin
expression
may
play
a
major
role
in
the
disease
progression
of
ESCC
patients
.
Particularly
,
the
distinct
expression
of
the
integrins
α
6
β
4
and
α
6
β
1
at
the
invasion
front
as
well
as
the
maintenance
of
a
polarized
integrin
expression
pattern
in
the
tumor
tissue
may
serve
as
valuable
new
markers
to
assess
the
aggressiveness
of
ESCC
.
Diseases
Validation
Diseases presenting
"squamous cell carcinoma"
symptom
carcinoma of the gallbladder
child syndrome
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kallmann syndrome
kindler syndrome
liposarcoma
monosomy 21
oculocutaneous albinism
oral submucous fibrosis
papillon-lefèvre syndrome
This symptom has already been validated
