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Integrin expression in esophageal squamous cell carcinoma: loss of the physiological integrin expression pattern correlates with disease progression.
[esophageal squamous cell carcinoma]
The
integrins
are
a
family
of
heterodimeric
transmembrane
signaling
receptors
that
mediate
the
adhesive
properties
of
epithelial
cells
affecting
cell
growth
and
differentiation
.
In
many
epithelial
malignancies
,
altered
integrin
expression
is
associated
with
tumor
progression
and
often
correlates
with
unfavorable
prognosis
.
However
,
only
few
studies
have
investigated
the
role
of
integrin
expression
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
Using
a
novel
quantifying
immunofluorescence-staining
assay
,
we
investigated
the
expression
of
the
integrins
α
2
β
1
,
α
3
β
1
,
α
6
β
1
,
and
α
6
β
4
in
primary
ESCC
of
36
patients
who
underwent
surgical
resection
.
Magnitude
and
distribution
of
expression
were
analyzed
in
primary
tumor
samples
and
autologous
esophageal
squamous
epithelium
.
The
persistence
of
the
physiologically
polarized
expression
of
the
subunits
α
6
,
β
1
,
and
β
4
in
the
tumor
tissue
was
significantly
associated
with
prolonged
relapse-free
survival
(
p
 
=
 
0
.
028
,
p
 
=
 
0
.
034
,
p
 
=
 
0
.
006
)
.
In
contrast
,
patients
with
reduced
focal
α
6
expression
at
the
tumor
invasion
front
shared
a
significantly
shortened
relapse-free
survival
compared
to
patients
with
strong
α
6
expression
at
their
stromal
surfaces
,
as
it
was
regularly
observed
in
normal
esophageal
epithelium
(
p
 
=
 
0
.
001
)
.
Multivariate
regression
analysis
identified
the
maintenance
of
strong
α
6
immunoreactivity
at
the
invasion
front
as
an
independent
prognostic
factor
for
increased
relapse-free
and
disease-
specific
survival
(
p
 
=
 
0
.
003
;
p
 
=
 
0
.
003
)
.
Our
findings
suggest
that
alterations
in
both
pattern
and
magnitude
of
integrin
expression
may
play
a
major
role
in
the
disease
progression
of
ESCC
patients
.
Particularly
,
the
distinct
expression
of
the
integrins
α
6
β
4
and
α
6
β
1
at
the
invasion
front
as
well
as
the
maintenance
of
a
polarized
integrin
expression
pattern
in
the
tumor
tissue
may
serve
as
valuable
new
markers
to
assess
the
aggressiveness
of
ESCC
.
Diseases
Validation
Diseases presenting
"prolonged relapse-free survival"
symptom
esophageal squamous cell carcinoma
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