MicroRNA-21 Promotes Cell Growth and Migration by Targeting Programmed Cell Death 4 Gene in Kazakh's Esophageal Squamous Cell Carcinoma.

[esophageal squamous cell carcinoma]

Esophageal cancer (EC ) is the eighth most common cancer worldwide and the sixth most common cause of cancer death . There are two main types of EC -squamous cell carcinoma (ESCC ) and adenocarcinoma (EAC ). Although some advances in the exploration of its possible etiological mechanism were made recently including behaviors and environmental risk factors as well as gene alterations , the molecular mechanism underlying ESCC carcinogenesis and progression remains poorly understood . It has been reported that miR-21 was upregulated in most malignant cancers , the proposed mechanism of which was through suppressing expression of programmed cell death 4 (PDCD 4 ). In present study , it is firstly reported that miR-21 was upregulated in Kazakh 's ESCC and that miR-21 played a negative role in regulating PDCD 4 using in situ hybridization (ISH ) and luciferase reporter approach . Morever , in model of ESCC xenografted nude mice , miR-21 maybe used as an effective target in the treatment . The present results demonstrated that miR-21 may be a potential therapeutic target in management of ESCC .

Diseases
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Diseases presenting "the sixth most common cause of cancer death" symptom

esophageal squamous cell carcinoma

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