Association of p53 expression with prognosis in patients with esophageal squamous cell carcinoma.

[esophageal squamous cell carcinoma]

It has been well accepted that p 53 overexpression is associated with advanced stages of cancer . However , the prognostic role of p 53 overexpression in esophageal squamous cell carcinoma (ESCC ) remains unclear . To investigate the prognostic role of p 53 overexpression in patients with ESCC , a retrospective cohort study of 136 ESCC patients was carried out . The expression of p 53 protein in tumor tissues was investigated immunohistochemically . Positive expression of p 53 protein was detected in 57 ESCC patients (41 .9 %). The p 53 overexpression was associated with smoking (P < 0 .001 ), tumor differentiation (P < 0 .001 ), and tumor size (P < 0 .001 ). In the Kaplan-Meier analysis , patients with p 53 overexpression had significantly shorter overall survival than those patients with negative p 53 expression (log-rank P < 0 .001 ). Multivariable analysis by Cox regression model further showed that p 53 overexpression was a significantly independent predictor of poorer overall survival (hazard ratio [HR ] = 1 .91 ; 95 % confidence interval [95 % CI ] 1 .03 -3 .54 , P = 0 .04 ). Thus , p 53 overexpression is associated with poor prognosis in patients with early stage esophageal squamous cell carcinoma , and it 's a significantly independent predictor of poorer overall survival .

Diseases
Validation

Diseases presenting "cancer" symptom

achondroplasia

acute rheumatic fever

adrenal incidentaloma

alpha-thalassemia

benign recurrent intrahepatic cholestasis

cadasil

canavan disease

carcinoma of the gallbladder

cholangiocarcinoma

coats disease

congenital adrenal hyperplasia

congenital diaphragmatic hernia

cowden syndrome

cushing syndrome

cutaneous mastocytosis

dedifferentiated liposarcoma

dystrophic epidermolysis bullosa

epidermolysis bullosa simplex

erdheim-chester disease

erythropoietic protoporphyria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

gm1 gangliosidosis

heparin-induced thrombocytopenia

hereditary cerebral hemorrhage with amyloidosis

hirschsprung disease

hodgkin lymphoma, classical

inclusion body myositis

junctional epidermolysis bullosa

kabuki syndrome

kallmann syndrome

kindler syndrome

lamellar ichthyosis

liposarcoma

locked-in syndrome

lymphangioleiomyomatosis

monosomy 21

neuralgic amyotrophy

oculocutaneous albinism

oligodontia

oral submucous fibrosis

papillon-lefèvre syndrome

pendred syndrome

pleomorphic liposarcoma

primary effusion lymphoma

proteus syndrome

pyomyositis

pyruvate dehydrogenase deficiency

severe combined immunodeficiency

sneddon syndrome

systemic capillary leak syndrome

triple a syndrome

von hippel-lindau disease

waldenström macroglobulinemia

well-differentiated liposarcoma

werner syndrome

wiskott-aldrich syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated