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Association of p53 expression with prognosis in patients with esophageal squamous cell carcinoma.
[esophageal squamous cell carcinoma]
It
has
been
well
accepted
that
p
53
overexpression
is
associated
with
advanced
stages
of
cancer
.
However
,
the
prognostic
role
of
p
53
overexpression
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
remains
unclear
.
To
investigate
the
prognostic
role
of
p
53
overexpression
in
patients
with
ESCC
,
a
retrospective
cohort
study
of
136
ESCC
patients
was
carried
out
.
The
expression
of
p
53
protein
in
tumor
tissues
was
investigated
immunohistochemically
.
Positive
expression
of
p
53
protein
was
detected
in
57
ESCC
patients
(
41
.
9
%
)
.
The
p
53
overexpression
was
associated
with
smoking
(
P
<
0
.
001
)
,
tumor
differentiation
(
P
<
0
.
001
)
,
and
tumor
size
(
P
<
0
.
001
)
.
In
the
Kaplan-
Meier
analysis
,
patients
with
p
53
overexpression
had
significantly
shorter
overall
survival
than
those
patients
with
negative
p
53
expression
(
log-rank
P
<
0
.
001
)
.
Multivariable
analysis
by
Cox
regression
model
further
showed
that
p
53
overexpression
was
a
significantly
independent
predictor
of
poorer
overall
survival
(
hazard
ratio
[
HR
]
=
1
.
91
;
95
%
confidence
interval
[
95
%
CI
]
1
.
03
-
3
.
54
,
P
=
0
.
04
)
.
Thus
,
p
53
overexpression
is
associated
with
poor
prognosis
in
patients
with
early
stage
esophageal
squamous
cell
carcinoma
,
and
it
's
a
significantly
independent
predictor
of
poorer
overall
survival
.
