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Immunohistochemical evidence of association between ghrelin expression and tumor growth in esophageal carcinoma.
[esophageal carcinoma]
Ghrelin
,
an
orexigenic
peptide
,
is
primarily
produced
and
secreted
by
the
gastrointestinal
tract
.
As
far
as
we
are
aware
of
,
there
is
no
evidence
of
ghrelin
expression
in
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
Two
hundred
and
ten
patients
with
ESCC
who
underwent
surgical
resection
were
enrolled
in
this
study
.
We
immunohistochemically
investigated
ghrelin
expression
in
primary
ESCC
specimens
and
analyzed
the
relationship
with
clinicopathological
factors
.
High
ghrelin
expression
was
observed
in
61
patients
(
29
.
0
%
)
.
Depth
of
tumor
invasion
and
histological
differentiation
were
statistically
associated
with
ghrelin
expression
.
As
for
depth
of
tumor
invasion
,
the
deeper
it
was
,
the
higher
was
the
expression
of
ghrelin
.
Well-differentiated
tumors
had
a
significantly
higher
proportion
of
ghrelin-expressing
cells
than
other
types
.
Ghrelin
expression
correlated
with
tumor
depth
and
tumor
differentiation
,
suggesting
an
important
role
of
ghrelin
in
tumor
growth
in
ESCC
.
