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Effect of physiological exercise on osteocalcin levels in subjects with adrenal incidentaloma.
[adrenal incidentaloma]
In
the
present
study
,
we
have
evaluated
whether
physical
exercise
affect
low
osteocalcin
concentrations
observed
in
patients
with
subclinical
hypercortisolism
.
Sixteen
patients
(
10
men
and
6
women
,
age
38
-
55
yr
)
with
adrenal
incidentaloma
were
studied
.
Fifteen
healthy
volunteers
matched
for
age
(
range
35
-
47
yr
)
were
used
as
controls
.
Subjects
were
submitted
to
a
8
-
week
exercise-training
program
with
cycle-ergometer
for
1
h
/
day
3
-
4
days
/
week
at
60
%
of
their
individual
VO
2
max
.
Before
and
after
this
period
,
resting
venous
serum
osteocalcin
and
GH
concentrations
were
measured
in
the
same
batch
.
The
blood
sampling
after
8
weeks
of
the
training
program
were
performed
after
resting
for
one
day
.
All
patients
and
controls
underwent
also
the
following
endocrine
evaluation
:
serum
cortisol
,
plasma
ACTH
.
Our
results
demonstrate
a
significant
increase
of
osteocalcin
after
physical
exercise
and
a
positive
correlation
between
osteocalcin
and
GH
.
This
later
might
suggest
a
role
of
GH
in
the
increased
osteocalcin
secretion
.
T
he
data
of
the
present
study
suggest
a
positive
effect
of
physical
exercise
on
bone
metabolism
in
patients
with
adrenal
incidentaloma
.
Diseases
Validation
Diseases presenting
"low osteocalcin concentrations"
symptom
adrenal incidentaloma
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