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Factors affecting long-term survival in elderly patients undergoing radiotherapy for esophageal carcinoma.
[esophageal carcinoma]
This
study
was
conducted
with
the
aim
to
analyze
the
factors
affecting
the
1
-
,
3
-
and
5
-
year
survival
rate
of
elderly
patients
with
esophageal
carcinoma
.
Between
2004
and
2008
,
a
total
of
371
patients
aged
≥
70
years
treated
with
radiotherapy
alone
were
enrolled
in
this
study
.
The
clinical
characteristics
and
radiotherapy
dose
were
evaluated
by
survival
rate
and
the
1
-
,
3
-
and
5
-
year
overall
survival
(
OS
)
rates
were
found
to
be
42
,
13
.
2
and
9
.
16
%
,
respectively
.
The
univariate
analysis
revealed
significant
differences
in
T
,
N
,
M
and
clinical
stage
and
radiotherapy
dose
(
all
P-
values
<
0
.
05
)
and
no
significant
differences
in
gender
(
all
P-
values
>
0
.
05
)
.
There
was
a
difference
in
tumor
location
when
only
comparing
the
3
-
and
5
-
year
OS
rates
(
P
=
0
.
031
and
P
=
0
.
025
,
respectively
)
.
The
multivariate
analysis
identified
clinical
stage
as
an
independent
factor
for
the
1
-
year
OS
rate
(
P
=
0
.
003
)
,
whereas
radiotherapy
dose
and
clinical
stage
were
found
to
be
independent
factors
for
the
3
-
and
5
-
year
OS
rates
(
all
P-
values
0
.
05
)
.
In
the
analysis
of
radiotherapy
dose
,
we
observed
no
significant
difference
in
the
1
-
year
OS
rate
between
the
radiation
dose
(
DT
)
>
60
Gy
and
the
50
Gy
≤
DT
<
60
Gy
groups
(
P
=
0
.
363
)
;
however
,
there
were
statistically
significant
differences
in
the
3
-
year
OS
rate
between
the
50
Gy
≤
DT
<
60
Gy
and
the
other
groups
(
P
=
0
.
039
and
P
=
0
.
032
)
;
there
were
no
significant
differences
in
the
5
-
year
OS
rate
among
the
dose
groups
(
all
P-
values
>
0
.
05
)
.
In
conclusion
,
according
to
the
findings
of
this
retrospective
study
,
radiotherapy
alone
for
elderly
patients
with
esophageal
cancer
does
not
appear
to
be
acceptable
and
there
is
a
need
for
a
more
effective
treatment
.
T
,
N
,
M
and
clinical
stage
and
radiotherapy
dose
were
identified
as
factors
significantly
affecting
the
1
-
,
3
-
and
5
-
year
OS
in
elderly
patients
with
esophageal
carcinoma
,
although
a
higher
radiotherapy
dose
with
normal
fractionation
did
not
appear
to
improve
the
OS
rate
.
Diseases
Validation
Diseases presenting
"stage as an independent factor"
symptom
esophageal carcinoma
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