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Application of sequential (18)F-FDG PET/CT scans for concurrent chemoradiotherapy of non-surgical squamous cell esophageal carcinoma.
[esophageal carcinoma]
To
explore
the
values
of
sequential
(
18
)
F-FDG
PET
/
CT
scanning
in
patients
with
non-surgical
esophageal
squamous
cell
carcinoma
(
ESCC
)
who
received
concurrent
chemoradiotherapy
(
CCRT
)
.
Twenty
-
eight
patients
with
pathologically
confirmed
stage
I
-IV
ESCC
and
who
received
definitive
CCRT
were
prospectively
enrolled
into
this
trial
.
The
(
18
)
F-FDG
PET
/
CT
scans
were
performed
four
times
.
The
maximum
standardized
uptake
values
(
SUVmax
)
of
each
scanning
were
named
as
SUVmaxpet
1
,
SUVmaxpet
2
,
SUVmaxpet
3
,
and
SUVmaxpet
4
,
respectively
.
The
tumor
volume
with
SUV
greater
than
40
%
of
SUVmax
was
named
as
metabolic
tumor
volume
(
MTV
)
.
Follow-up
investigation
of
patients
was
performed
to
record
progression-free
survival
(
PFS
)
,
relapse-free
survival
(
RFS
)
,
and
overall
survival
time
(
OS
)
.
The
average
value
of
MTV
before
treatment
is
19
.
3
ml
.
The
average
value
of
SUVmax
at
four
time
points
was
13
.
0
±
7
.
4
,
6
.
4
±
3
.
2
,
4
.
7
±
1
.
9
,
and
3
.
4
±
1
.
8
,
respectively
.
Median
follow-up
time
was
18
.
5
months
(
range
5
-
40
)
.
There
was
statistically
significant
difference
in
ΔR
14
(
(
SUVmaxpet
1
-
SUVmaxpet
4
)
/
SUVmaxpet
1
)
.
Multivariate
Cox
regression
survival
analysis
indicated
that
the
MTV
was
an
independent
prognostic
factor
for
PFS
and
RFS
(
HR
=
1
.
13
and
1
.
14
,
respectively
)
before
treatment
.
In
CCRT
of
non-surgical
ESCC
,
MTV
before
treatment
could
independently
predict
OS
survival
.
SUVmaxpet
2
,
SUVmaxpet
3
,
and
SUVmaxpet
4
could
predict
RFS
.
Patients
with
reductions
of
SUVmaxpet
4
less
than
75
%
had
a
poor
PFS
,
RFS
,
and
OS
.
Diseases
Validation
Diseases presenting
"median follow-up time"
symptom
congenital adrenal hyperplasia
cushing syndrome
cutaneous mastocytosis
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
omenn syndrome
severe combined immunodeficiency
von hippel-lindau disease
wiskott-aldrich syndrome
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