Overexpression of interleukin-8 receptor 2 (IL-8R2) indicates better prognosis in esophageal adenocarcinoma and squamous cell carcinoma procession.

[esophageal carcinoma]

Researches have showed that interleukin family or receptors play a role in many human tumor progressions including esophageal carcinoma . In this study , we examined the expression of interleukin-8 receptor 2 (IL -8 R 2 ) and analyze the relationship between it and esophageal carcinoma clinical characteristics . IL -8 R 2 protein expression was confirmed by immunohistochemistry and immunofluorescence arrays and was analyzed further via Western blot and qRT-PCR analysis in frozen tissues . The correlation between their expression levels and clinical characteristics were evaluated by Mann-Whitney and Kruskal-Wallis test . Via Kaplan-Meier plots and Cox proportional hazard models , overall survival (OS ) was analyzed . Compared with normal esophageal tissue , IL -8 R 2 protein was overexpressed significantly in esophageal cancer (p < 0 .05 ) and was observed both in cytoplasm and nuclear . The lower expression of IL -8 R 2 protein was observed with higher p staging of esophageal cancer , and the significant association between them was confirmed (p = 0 .000 ), and in advanced p T stage , the similar result was obtained (p = 0 .015 ); however , compared with lymph node metastasis-negative group , it is no significant difference in positive group (p = 0 .152 ). In a Kaplan-Meier analysis , compared with IL -8 R 2 low expression , IL -8 R 2 high expression identified a group of patients with the longest OS . Cox proportional hazard models revealed that IL -8 R 2 predicted long time to OS . The higher expression of IL -8 R 2 was found in early esophageal carcinoma , which may indicate that IL -8 R 2 plays an important role and is better prognostic factor in esophageal cancer development .