Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Homozygous GNAS 393C-Allele Carriers with Locally Advanced Esophageal Cancer Fail to Benefit from Platinum-Based Preoperative Chemoradiotherapy.
[esophageal carcinoma]
Currently
,
patients
with
locally
advanced
esophageal
cancer
receive
neoadjuvant
chemoradiotherapy
but
only
about
half
of
these
patients
benefit
from
this
treatment
.
GNAS
T
393
C
has
been
shown
to
predict
the
postoperative
course
in
solid
tumors
and
may
therefore
be
useful
for
treatment
stratification
.
The
aim
of
the
present
study
was
to
determine
if
the
single
-nucleotide
polymorphism
GNAS
T
393
C
can
be
used
for
treatment
stratification
in
esophageal
cancer
patients
.
A
total
of
596
patients
underwent
surgical
resection
for
esophageal
carcinoma
from
1996
to
2008
;
279
patients
received
chemoradiotherapy
prior
to
surgery
(
RTX-SURG
group
)
.
All
patients
and
a
reference
group
of
820
healthy
White
individuals
were
genotyped
for
GNAS
T
393
C
.
The
5
-
year
-survival
rate
for
the
317
patients
who
underwent
esophagectomy
as
initial
treatment
(
SURG
group
)
was
57
%
for
homozygous
C-
allele
carriers
(
n
=
99
)
and
43
%
for
T
-
allele
carriers
(
n
=
218
;
log-
rank
test
p
=
0
.
025
)
.
Multivariate
analysis
revealed
the
GNAS
T
393
C
genotype
(
p
=
0
.
034
)
,
pT
(
p
<
0
.
001
)
,
pN
(
p
<
0
.
001
)
and
age
(
p
<
0
.
001
)
as
prognostic
of
survival
.
Homozygous
C-
allele
carriers
with
a
locally
advanced
tumor
stage
(
cT
3
/
T
4
,
n
=
129
)
in
the
SURG
group
had
a
5
-
year
survival
rate
of
37
%
,
which
,
remarkably
,
exceeded
the
5
-
year
survival
rate
of
30
%
for
the
entire
RTX-SURG
group
(
n
=
279
)
.
In
the
RTX-SURG
group
,
the
GNAS
T
393
C
genotype
did
not
show
any
prognostic
significance
.
Patients
with
a
locally
advanced
esophageal
cancer
and
an
homozygous
GNAS
393
C
genotype
do
not
benefit
from
platinum-based
neoadjuvant
chemoradiotherapy
,
indicating
that
these
patients
should
be
treated
by
alternative
treatment
strategies
.
Diseases
Validation
Diseases presenting
"that these patients should be treated by alternative treatment strategies"
symptom
esophageal carcinoma
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom