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Treatment outcomes after intraluminal brachytherapy following definitive chemoradiotherapy in patients with esophageal cancer.
[esophageal carcinoma]
To
report
the
results
of
treatment
with
intraluminal
brachytherapy
(
ILRT
)
after
concurrent
chemoradiotherapy
for
esophageal
carcinoma
with
respect
to
disease
free
survival
(
DFS
)
,
dysphagia
free
interval
(
DFI
)
,
and
complications
of
treatment
.
The
study
retrospectively
analyzed
the
records
of
26
eligible
patients
with
nonmetastatic
carcinoma
of
the
esophagus
treated
with
definitive
chemoradiotherapy
followed
by
ILRT
between
2008
and
2011
.
The
DFS
and
DFI
were
estimated
and
factors
likely
to
influence
them
were
analyzed
.
Nineteen
(
73
%
)
patients
were
males
.
The
mean
age
at
presentation
was
60
years
(
range
:
47
-
90
years
)
.
All
the
patients
had
squamous
cell
carcinomas
.
Following
treatment
,
the
median
DFS
was
12
.
7
months
(
range
:
0
-
27
months
)
.
Sixteen
patients
(
61
.
5
%
)
had
local
control
of
their
disease
,
while
one
had
residual
disease
at
completion
of
treatment
.
Other
than
three
patients
who
were
not
evaluated
for
recurrent
dysphagia
,
six
(
23
.
1
%
)
had
proven
local
recurrence
on
follow-up
.
The
estimated
mean
DFI
was
13
.
8
months
(
range
:
0
-
27
months
)
.
One
patient
died
of
tracheoesophageal
fistula
following
treatment
.
On
statistical
analysis
,
only
the
location
of
tumor
was
prognostically
significant
,
with
lower
third
tumors
performing
worse
.
Other
probable
predictors
of
poor
outcome
included
large
volume
(
>
40
cc
)
,
tumor
length
(
>
6
cm
)
,
and
eccentric
location
.
ILRT
boost
following
concurrent
chemoradiotherapy
is
well
tolerated
and
potentially
improves
outcomes
.
It
might
be
beneficial
in
selected
patients
with
esophageal
carcinoma
.
Further
studies
are
required
to
identify
its
role
in
definitive
treatment
.
Diseases
Validation
Diseases presenting
"large volume"
symptom
esophageal carcinoma
proteus syndrome
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