ABO blood group and esophageal carcinoma risk: from a case-control study in Chinese population to meta-analysis.

[esophageal carcinoma]

The association between ABO blood group and the risk of esophageal carcinoma (EC ) in previously published studies is uncertain and conflicting . The aim of the current study was to determine the correlation of ABO blood group with EC risk via a case-control study and meta -analysis .We performed a population-based case-control study of 3 ,595 cases and 41 ,788 controls in Chinese population to evaluate the association between ABO blood group and EC risk . Then , a comprehensive meta -analysis combining our original data and previously published data was conducted to clearly discern the real relationship . The strength of association was measured by odds ratios (ORs ) with 95 Â % confidence intervals (CI ).In our case-control study , the risk of EC in blood group B was significantly higher than that in non-B groups (A , O , and AB ) (OR Â =Â 1 .15 , 95 Â % CI 1 .09 -1 .21 ). Compared with non-O groups (A , B , and AB ), individuals with blood group O demonstrated a reduced risk of EC (OR Â =Â 0 .90 , 95 Â % CI 0 .85 -0 .94 ). The meta -analysis also indicated that blood group B was associated with significantly higher EC risk (OR Â =Â 1 .20 , 95 Â % CI 1 .10 -1 .31 ), and people with blood group O had a decreased EC risk (OR Â =Â 0 .94 , 95 Â % CI 0 .90 -0 .99 ). Neither the case-control study nor the meta -analysis produced any significant association of blood group A or AB with EC risk .Results from our case-control study and the followed meta -analysis confirmed that there was an increased risk of EC in blood group B individuals , whereas a decreased risk of EC was observed in blood group O individuals .