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CecropinXJ, a silkworm antimicrobial peptide, induces cytoskeleton disruption in esophageal carcinoma cells.
[esophageal carcinoma]
Antimicrobial
peptides
exist
in
the
non-
specific
immune
system
of
organism
and
participate
in
the
innate
host
defense
of
each
species
.
CecropinXJ
,
a
cationic
antimicrobial
peptide
,
possesses
potent
anticancer
activity
and
acts
preferentially
on
cancer
cells
instead
of
normal
cells
,
but
the
mechanism
of
cancer
cell
death
induced
by
cecropinXJ
remains
largely
unknown
.
This
study
was
performed
to
investigate
the
cytoskeleton-disrupting
effects
of
cecropinXJ
on
human
esophageal
carcinoma
cell
line
Eca
109
using
scanning
electron
microscopy
observation
,
fluorescence
imaging
,
cell
migration
and
invasion
assays
,
western
blotting
,
and
quantitative
reverse
transcription
polymerase
chain
reaction
(
qRT-PCR
)
analysis
.
The
electronic
microscope
and
fluorescence
imaging
observation
suggested
that
cecropinXJ
could
result
in
morphological
changes
and
induce
damage
to
microtubules
and
actin
of
Eca
109
cells
in
a
dose-dependent
manner
.
The
cell
migration
and
invasion
assays
demonstrated
that
cecropinXJ
could
inhibit
migration
and
invasion
of
tumor
cells
.
Western
blot
and
qRT-PCR
analysis
showed
that
there
was
obvious
correlation
between
microtubule
depolymerization
and
actin
polymerization
induced
by
cecropinXJ
.
Moreover
,
cecropinXJ
might
also
cause
decreased
expression
of
α-actin
,
β-actin
,
γ-actin
,
α-tubulin
,
and
β-tubulin
genes
in
concentration-
and
time-dependent
manners
.
In
summary
,
this
study
indicates
that
cecropinXJ
triggers
cytotoxicity
in
Eca
109
cells
through
inducing
the
cytoskeleton
destruction
and
regulating
the
expression
of
cytoskeleton
proteins
.
This
cecropinXJ-mediated
cytoskeleton-destruction
effect
is
instrumental
in
our
understanding
of
the
detailed
action
of
antimicrobial
peptides
in
human
cancer
cells
and
cecropinXJ
might
be
a
potential
therapeutic
agent
for
the
treatment
of
cancer
in
the
future
.
Diseases
Validation
Diseases presenting
"tumor cells"
symptom
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
dedifferentiated liposarcoma
dentin dysplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
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