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Prognostic significance of beta-catenin expression in patients with esophageal carcinoma: a meta-analysis.
[esophageal carcinoma]
Many
studies
have
reported
β-catenin
involvement
in
the
development
of
esophageal
carcinoma
(
EC
)
,
but
its
prognostic
significance
for
EC
patients
remains
controversial
.
Therefore
,
we
conducted
this
meta
-analysis
to
explore
the
issue
in
detail
.
After
searching
PubMed
,
EMBASE
,
Web
of
Science
,
and
Chinese
Biomedical
Literature
Database
,
we
included
a
total
of
ten
relevant
studies
.
We
pooled
the
overall
survival
(
OS
)
data
using
RevMan
5
.
2
software
.
The
results
showed
that
aberrant
expression
of
β-catenin
was
associated
with
a
significant
increase
of
mortality
risk
(
hazard
ratio
1
.
71
,
95
%
CI
1
.
46
-
2
.
01
;
p
<
0
.
00001
)
.
Subgroup
analyses
further
suggested
that
aberrant
expression
of
β-catenin
resulted
in
poor
OS
of
EC
patients
regardless
of
histological
type
of
EC
,
study
location
or
criteria
for
aberrant
expression
of
β-catenin
,
and
the
sensitivity
analyses
revealed
that
the
result
was
robust
.
The
meta
-analysis
revealed
that
aberrant
expression
of
β-catenin
could
be
a
predicative
factor
of
poor
prognosis
for
EC
patients
.
