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Long noncoding RNA HOTAIR as an independent prognostic marker in cancer: a meta-analysis.
[esophageal carcinoma]
HOTAIR
,
a
newly
discovered
long
intergenic
noncoding
RNA
(
lincRNA
)
,
has
been
reported
to
be
aberrantly
expressed
in
many
types
of
cancers
.
This
meta
-analysis
summarizes
its
potential
role
as
a
biomarker
in
malignancy
.
A
quantitative
meta
-analysis
was
performed
through
a
systematic
search
in
Pubmed
,
Medline
and
Web
of
Science
for
eligible
papers
on
the
prognostic
impact
of
HOTAIR
in
cancer
from
inception
to
Feb
.
28
,
2014
.
Pooled
hazard
ratios
(
HRs
)
with
95
%
confidence
interval
(
95
%
CI
)
were
calculated
to
summarize
the
effect
.
Nineteen
studies
were
included
in
the
study
,
with
a
total
of
2033
patients
.
A
significant
association
was
observed
between
high
HOTAIR
expression
and
poor
overall
survival
(
OS
)
in
patients
with
cancer
(
pooled
HR
2
.
22
,
95
%
CI
:
1
.
68
-
2
.
93
)
.
Place
of
residence
(
Asian
or
Western
countries
)
,
type
of
cancer
(
digestive
or
non-digestive
disease
)
,
sample
size
(
more
or
less
than
100
)
,
and
paper
quality
(
score
more
or
less
than
85
%
)
did
not
alter
the
significant
predictive
value
of
HOTAIR
in
OS
from
various
kinds
of
cancer
but
preoperative
status
did
.
By
combining
HRs
from
Cox
multivariate
analyses
,
we
found
that
HOTAIR
expression
was
an
independent
prognostic
factor
for
cancer
patients
(
pooled
HR
2
.
26
,
95
%
CI
:
1
.
62
-
3
.
15
)
.
Subgroup
analysis
showed
that
HOTAIR
abundance
was
an
independent
prognostic
factor
for
cancer
metastasis
(
HR
3
.
90
,
95
%
CI
:
2
.
25
-
6
.
74
)
.
For
esophageal
carcinoma
,
high
HOTAIR
expression
was
significantly
associated
with
TNM
stage
(
III
/
IV
vs
.
I
/
II
:
OR
6
.
90
,
95
%
CI
:
2
.
81
-
16
.
9
)
without
heterogeneity
.
In
gastric
cancer
,
HOTAIR
expression
was
found
to
be
significantly
associated
with
lymph
node
metastases
(
present
vs
.
absent
:
OR
4
.
47
,
95
%
CI
:
1
.
88
-
10
.
63
)
and
vessel
invasion
(
positive
vs
.
negative
:
OR
2
.
88
,
95
%
CI
:
1
.
38
-
6
.
04
)
without
obvious
heterogeneity
.
HOTAIR
abundance
may
serve
as
a
novel
predictive
factor
for
poor
prognosis
in
different
types
of
cancers
in
both
Asian
and
Western
countries
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
