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ERCC1 single nucleotide polymorphism C8092A, but not its expression is associated with survival of esophageal squamous cell carcinoma patients from Fujian province, China.
[esophageal carcinoma]
Esophageal
carcinoma
is
one
of
the
world
's
deadliest
cancers
.
Esophageal
squamous
cell
carcinoma
(
ESCC
)
is
more
frequent
than
adenocarcenoma
(
AC
)
in
China
.
Platinum
-based
chemotherapy
with
surgical
resection
is
a
common
treatment
approach
for
ESCC
;
however
,
the
treatment
response
is
uncertain
.
Evidence
suggests
polymorphisms
in
genes
encoding
excision
repair
cross-complementing
group
1
(
ERCC
1
)
,
a
protein
involved
in
nuclear
excision
repair
(
NER
)
,
may
help
predict
response
to
cisplatin
and
other
platinum-based
chemotherapeutics
.
Multiple
ERCC
1
single
nucleotide
polymorphisms
(
SNPs
)
have
been
associated
with
platinum
chemotherapy
response
.
Two
common
SNPs
occur
at
the
C
8092
A
and
C
118
T
loci
.
Our
study
aimed
to
determine
if
1
)
an
association
exists
between
ERCC
1
tumor
expression
and
patient
survival
,
2
)
whether
adjuvant
therapy
influence
on
survival
is
related
to
histological
ERCC
1
presence
in
tumor
cell
nuclei
,
and
3
)
whether
other
clinicopathological
characteristics
in
a
cohort
of
patients
following
surgery
for
various
stages
of
ESCC
are
associated
with
tumor
ERCC
1
expression
.
One
hundred
eight
patients
were
included
in
the
study
,
and
tumor
biopsy
was
collected
for
genotyping
and
immunohistochemical
analysis
of
ERCC
1
.
Sixty
-
seven
patients
(
62
%
)
received
no
adjuvant
therapy
,
and
the
rest
had
either
platinum-based
chemotherapy
(
28
.
5
%
)
,
radiotherapy
(
6
.
5
%
)
or
both
treatments
(
2
.
8
%
)
.
Log-rank
analysis
revealed
no
significant
connection
between
tumor
ERCC
1
expression
(
P
=
0
.
12
)
or
adjuvant
therapy
(
P
=
0
.
56
)
on
patient
survival
.
Also
,
non-parametric
Mann-
Whitney
analysis
showed
no
significant
link
between
tumor
size
or
nodus
tumor
formation
and
ERCC
1
presence
in
patients
in
the
study
.
Interestingly
,
C
8092
A
SNP
showed
significant
association
with
patient
survival
(
P
=
0
.
01
)
,
with
patients
homozygous
for
the
mutant
allele
showing
the
most
significantly
reduced
survival
(
P
=
0
.
04
)
compared
to
those
homozygous
for
the
dominant
allele
(
CC
)
.
Our
results
provide
novel
insight
into
the
genotypic
variation
of
patients
from
Quanzhou
,
Fujian
province
China
.
Diseases
Validation
Diseases presenting
"tumor cell nuclei"
symptom
esophageal carcinoma
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