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Monitoring the early biologic response of esophageal carcinoma after irradiation with 18F-FLT: an in-vitro and in-vivo study.
[esophageal carcinoma]
The
aim
of
our
study
was
to
explore
the
value
of
3
'
-
deoxy-
3
'
-
[
F
]
fluorothymidine
(
F-FLT
)
and
F-FLT
PET
in
monitoring
the
early
biologic
response
of
esophageal
carcinoma
after
irradiation
in
vitro
and
in
vivo
.
After
2
,
4
,
and
8
 
h
of
irradiation
at
different
doses
(
0
,
5
,
10
,
and
15
 
Gy
)
of
esophageal
carcinoma
cells
in
vitro
,
the
uptake
ratio
of
F-FLT
,
the
relative
cell
survival
rate
,
and
ATP
levels
were
measured
.
The
tumor
uptake
ratio
of
F-FLT
[
tumor
-
to
-nontumor
(
T
/
NT
)
]
was
measured
through
PET
scans
before
and
on
the
first
,
seventh
,
and
15
th
day
after
irradiation
.
The
expression
of
proliferating
cell
nuclear
antigen
and
Ki-
67
was
determined
in
both
untreated
and
treated
tumors
.
Compared
with
the
control
group
,
the
uptake
ratio
changes
of
F-FLT
after
2
 
h
of
irradiation
with
5
 
Gy
showed
no
statistical
significance
(
3
.
65
±
0
.
17
vs
.
4
.
00
±
0
.
17
%
,
P
>
0
.
05
)
,
whereas
the
uptake
ratios
of
the
other
groups
decreased
notably
(
F
=
33
.
93
,
P
<
0
.
01
)
.
The
differences
in
the
relative
survival
rates
were
not
statistically
significant
(
F
=
4
.
02
,
P
>
0
.
05
)
.
Linear
regression
analysis
indicated
a
significant
correlation
between
F-FLT
and
ATP
levels
(
r
=
0
.
89
,
P
<
0
.
01
)
.
On
F-FLT
PET
scan
images
of
the
xenografts
,
the
baseline
uptake
ratio
(
T
/
NT
)
was
2
.
24
±
0
.
06
.
It
decreased
to
1
.
99
±
0
.
09
,
1
.
85
±
0
.
04
,
and
1
.
15
±
0
.
10
at
1
,
7
,
and
15
days
after
irradiation
with
10
 
Gy
.
Tumor
uptake
of
F-FLT
was
closely
correlated
with
proliferating
cell
nuclear
antigen
and
Ki-
67
expressions
(
r
=
0
.
83
,
P
<
0
.
001
,
and
r
=
0
.
88
,
P
<
0
.
001
)
.
The
uptake
changes
of
F-FLT
in
esophageal
carcinoma
cells
and
tumor
xenografts
may
reflect
the
early
biological
response
of
esophageal
carcinoma
after
irradiation
.
Thus
,
F-FLT
PET
may
be
potentially
used
to
monitor
the
early
response
of
esophageal
carcinoma
after
radiotherapy
.
Diseases
Validation
Diseases presenting
"early response"
symptom
congenital diaphragmatic hernia
esophageal carcinoma
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