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Myricetin exerts anti-proliferative, anti-invasive, and pro-apoptotic effects on esophageal carcinoma EC9706 and KYSE30 cells via RSK2.
[esophageal carcinoma]
Myricetin
,
a
common
dietary
flavonoid
,
is
widely
distributed
in
fruits
and
vegetables
and
is
used
as
a
health
food
supplement
based
on
its
anti-
tumor
properties
.
However
,
the
effect
and
mechanisms
of
myricetin
in
esophageal
carcinoma
are
not
fully
understood
.
Here
,
we
demonstrated
the
effect
of
myricetin
on
the
proliferation
,
apoptosis
,
and
invasion
of
the
esophageal
carcinoma
cell
lines
EC
9706
and
KYSE
30
and
explored
the
underlying
mechanism
and
target
protein
(
s
)
of
myricetin
.
CCK
-
8
assay
,
transwell
invasion
assay
,
wound-healing
assay
,
cell
cycle
analysis
,
and
apoptosis
assay
were
used
to
evaluate
the
effects
of
myricetin
on
cell
proliferation
,
invasion
,
and
apoptosis
.
Nude
mouse
tumor
xenograft
model
was
built
to
understand
the
interaction
between
myricetin
and
NTD
RSK
2
.
Pull-down
assay
was
used
to
verify
molecular
mechanism
.
Myricetin
inhibited
proliferation
and
invasion
and
induced
apoptosis
of
EC
9706
and
KYSE
30
cells
.
Moreover
,
myricetin
was
shown
to
bind
RSK
2
through
the
NH
2
-
terminal
kinase
domain
.
Finally
,
myricetin
inhibited
EC
9706
and
KYSE
30
cell
proliferation
through
Mad
1
and
induced
cell
apoptosis
via
Bad
.
Myricetin
inhibits
the
proliferation
and
invasion
and
induces
apoptosis
in
EC
9706
and
KYSE
30
cells
via
RSK
2
.
Myricetin
exerts
anti-proliferative
,
anti-invasive
,
and
pro-apoptotic
effects
on
esophageal
carcinoma
EC
9706
and
KYSE
30
cells
via
RSK
2
.
Our
results
provide
novel
insight
into
myricetin
as
a
potential
agent
for
the
prevention
and
treatment
of
esophageal
carcinoma
.
Diseases
Validation
Diseases presenting
"esophageal carcinoma"
symptom
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
This symptom has already been validated