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CBX8, a novel DNA repair protein, promotes tumorigenesis in human esophageal carcinoma.
[esophageal carcinoma]
DNA
damage
response
and
repair
are
carried
out
by
certain
proteins
following
damage
by
environmental
clastogens
,
such
as
ionizing
radiation
and
reactive
oxygen
species
.
It
has
been
reported
that
many
carcinomas
that
are
characterized
by
resistance
to
chemotherapy
and
poor
outcomes
show
dysfunction
of
these
proteins
.
Chromobox
homologue
8
(
CBX
8
)
,
a
member
of
the
polycomb
group
of
proteins
,
has
been
identified
as
a
factor
that
protects
tumor
cells
from
the
detrimental
effects
of
ionizing
radiation
(
IR
)
or
hydrogen
peroxide
(
H
2
O
2
)
.
In
this
study
,
we
found
that
CBX
8
was
up-regulated
in
esophageal
carcinoma
tissues
compared
with
adjacent
non-cancerous
tissues
(
P
<
0
.
01
)
and
correlated
with
TNM
stage
in
esophageal
squamous
cell
carcinoma
patients
.
Depletion
of
CBX
8
decreased
cell
proliferation
both
in
vitro
and
in
vivo
and
increased
the
phosphorylation
levels
of
p
21
,
Wee
1
,
and
CHK
1
,
which
result
in
cyclin-dependent
kinase
inhibition
and
cell-cycle
delay
.
CBX
8
depletion
also
led
to
accumulation
of
spontaneous
DNA
damage
and
raised
the
sensitivity
of
tumor
cells
to
IR
or
H
2
O
2
.
We
also
found
that
the
total
level
of
CBX
8
in
the
cells
was
increased
after
treating
tumor
cells
with
clastogens
.
In
addition
,
our
data
showed
that
decreased
CBX
8
expression
was
accompanied
by
the
reduction
of
EZH
2
and
EED
,
which
have
been
reported
to
participate
in
DNA
damage
repair
.
Collectively
,
CBX
8
might
emerge
as
an
oncogene
for
promoting
the
proliferation
of
tumor
cells
and
raising
the
resistance
of
neoplasms
to
chemotherapy
.
Diseases
Validation
Diseases presenting
"tumor cells"
symptom
alpha-thalassemia
carcinoma of the gallbladder
cholangiocarcinoma
cushing syndrome
dedifferentiated liposarcoma
dentin dysplasia
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
severe combined immunodeficiency
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
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