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Human umbilical cord mesenchymal stem cells promote carcinoma growth and lymph node metastasis when co-injected with esophageal carcinoma cells in nude mice.
[esophageal carcinoma]
Human
umbilical
cord
blood
derived-mesenchymal
stem
cells
(
hUCMSCs
)
offer
an
attractive
alternative
to
bone
marrow-derived
MSCs
(
BMMSCs
)
for
cell-based
therapy
as
it
is
a
less
invasive
source
of
biological
material
.
However
,
limited
studies
have
been
conducted
with
hUCMSCs
as
compared
to
BMMSCs
.
The
present
study
was
conducted
to
evaluate
the
effects
of
hUCMSCs
in
esophageal
carcinoma
(
EC
)
.
hUCMSCs
together
with
EC
cells
were
transplanted
subcutaneously
into
BALB
/
c
nude
mice
to
observe
the
effects
of
hUCMSCs
on
tumor
establishment
.
hUCMSCs
injected
through
the
caudal
vein
to
the
mice
with
pre-established
EC
to
observe
the
effects
of
hUCMSCs
on
tumor
outgrowth
.
In
order
to
elucidate
the
underlying
mechanisms
,
we
also
performed
in
vitro
experiments
including
directly
co
-culture
,
transwell
assay
,
proliferation
assay
and
western
blotting
analysis
.
hUCMSCs
promoted
EC
formation
in
nude
mice
.
In
the
in
vivo
model
of
pre-established
EC
,
intravenously
injected
hUCMSCs
potently
promoted
tumor
growth
.
When
in
vitro
co
-cultured
with
hUCMSCs
,
EC
cells
proliferation
increased
.
After
co
-cultured
with
hUCMSCs
through
transwell
system
,
EC
cells
showed
increased
proliferation
.
Through
transwell
assay
,
we
also
observed
that
EC
cells
recruited
MSCs
,
and
MSCs
promoted
EC
cells
migration
and
invasion
.
Western
blotting
data
showed
that
the
expressions
of
proliferation
related
proteins
Bcl-
2
,
survivin
and
metastasis
related
proteins
MMP-
2
and
MMP-
9
were
up-regulated
in
the
EC
cells
transwell
co
-cultured
with
hUCMSCs
.
Our
results
indicated
that
hUCMSCs
could
favor
tumor
growth
in
vivo
and
in
vitro
.
Thus
,
the
exploitation
of
hUCMSCs
in
new
therapeutic
strategies
should
be
cautious
under
the
malignant
conditions
.
Diseases
Validation
Diseases presenting
"tumor growth"
symptom
adrenal incidentaloma
carcinoma of the gallbladder
cholangiocarcinoma
cowden syndrome
cystinuria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
liposarcoma
lymphangioleiomyomatosis
primary effusion lymphoma
severe combined immunodeficiency
von hippel-lindau disease
waldenström macroglobulinemia
wiskott-aldrich syndrome
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