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Human umbilical cord mesenchymal stem cells promote carcinoma growth and lymph node metastasis when co-injected with esophageal carcinoma cells in nude mice.
[esophageal carcinoma]
Human
umbilical
cord
blood
derived-mesenchymal
stem
cells
(
hUCMSCs
)
offer
an
attractive
alternative
to
bone
marrow-derived
MSCs
(
BMMSCs
)
for
cell-based
therapy
as
it
is
a
less
invasive
source
of
biological
material
.
However
,
limited
studies
have
been
conducted
with
hUCMSCs
as
compared
to
BMMSCs
.
The
present
study
was
conducted
to
evaluate
the
effects
of
hUCMSCs
in
esophageal
carcinoma
(
EC
)
.
hUCMSCs
together
with
EC
cells
were
transplanted
subcutaneously
into
BALB
/
c
nude
mice
to
observe
the
effects
of
hUCMSCs
on
tumor
establishment
.
hUCMSCs
injected
through
the
caudal
vein
to
the
mice
with
pre-established
EC
to
observe
the
effects
of
hUCMSCs
on
tumor
outgrowth
.
In
order
to
elucidate
the
underlying
mechanisms
,
we
also
performed
in
vitro
experiments
including
directly
co
-culture
,
transwell
assay
,
proliferation
assay
and
western
blotting
analysis
.
hUCMSCs
promoted
EC
formation
in
nude
mice
.
In
the
in
vivo
model
of
pre-established
EC
,
intravenously
injected
hUCMSCs
potently
promoted
tumor
growth
.
When
in
vitro
co
-cultured
with
hUCMSCs
,
EC
cells
proliferation
increased
.
After
co
-cultured
with
hUCMSCs
through
transwell
system
,
EC
cells
showed
increased
proliferation
.
Through
transwell
assay
,
we
also
observed
that
EC
cells
recruited
MSCs
,
and
MSCs
promoted
EC
cells
migration
and
invasion
.
Western
blotting
data
showed
that
the
expressions
of
proliferation
related
proteins
Bcl-
2
,
survivin
and
metastasis
related
proteins
MMP-
2
and
MMP-
9
were
up-regulated
in
the
EC
cells
transwell
co
-cultured
with
hUCMSCs
.
Our
results
indicated
that
hUCMSCs
could
favor
tumor
growth
in
vivo
and
in
vitro
.
Thus
,
the
exploitation
of
hUCMSCs
in
new
therapeutic
strategies
should
be
cautious
under
the
malignant
conditions
.
Diseases
Validation
Diseases presenting
"malignant conditions"
symptom
esophageal carcinoma
waldenström macroglobulinemia
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