Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
[Effect of NF-κB activation on the radiation response of esophageal cancer cells].
[esophageal carcinoma]
To
investigate
the
effect
of
NF-κB
activation
on
radiation
response
of
esophageal
carcinoma
.
The
expression
of
NF-κB
was
detected
in
pretreatment
and
posttreatment
specimens
of
patients
with
ESCC
by
immunohistochemistry
.
Electrophoretic
mobility
shift
assay
(
EMSA
)
and
Western
blot
were
used
to
detect
the
activation
of
NF-κB
in
esophageal
cancer
cell
line
KYSE
150
cells
.
SN
50
,
a
specific
NF-κB
inhibitor
,
was
applied
to
inhibit
the
activation
of
NF-κB
.
Clone
formation
test
was
used
to
detect
the
radiosensitivity
of
esophageal
cancer
cells
.
The
median
survival
time
of
patients
with
activated
and
inactivated
NF-κB
in
the
pretreatment
specimens
were
16
and
19
months
,
respectively
,
with
a
non-significant
difference
between
the
two
groups
(
P
>
0
.
05
)
.
As
to
the
patients
with
activated
and
inactivated
NF-κB
in
posttreatment
specimens
,
the
median
survival
times
were
13
and
35
months
,
respectively
,
with
a
significant
difference
(
P
<
0
.
01
)
between
them
.
Western
blot
showed
that
the
cytoplasmic
expression
of
NF-κB
was
reduced
with
increasing
radiation
dose
at
1
.
5
and
3
hours
after
radiation
treatment
.
However
,
the
expression
of
NF-κB
in
the
cell
nuclei
was
increased
under
the
same
condition
,
showing
a
trend
of
increased
nucleus
/
cytoplasm
ratio
.
The
clone
number
in
SN
50
group
was
96
.
66
,
64
.
66
,
76
.
66
and
10
.
00
under
0
,
2
,
4
and
12
Gy
irradiation
,
which
demonstrated
a
significant
difference
compared
with
the
control
groups
(
P
<
0
.
001
)
.
Our
results
show
that
activation
of
NF-κB
is
induced
by
radiotherapy
.
Activation
of
NF-κB
reduces
the
outcome
of
radiation
treatment
of
esophageal
cancer
patients
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
