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Cytoprotective effects of hydrogen sulfide in novel rat models of non-erosive esophagitis.
[esophageal carcinoma]
Non-erosive
esophagitis
is
a
chronic
inflammatory
condition
of
the
esophagus
and
is
a
form
of
gastroesophageal
reflux
disease
.
There
are
limited
treatment
options
for
non-erosive
esophagitis
,
and
it
often
progresses
to
Barrett
's
esophagus
and
esophageal
carcinoma
.
Hydrogen
sulfide
has
been
demonstrated
to
be
a
critical
mediator
of
gastric
and
intestinal
mucosal
protection
and
repair
.
However
,
roles
for
H
2
S
in
esophageal
mucosal
defence
,
inflammation
and
responses
to
injury
have
not
been
reported
.
We
therefore
examined
the
effects
of
endogenous
and
exogenous
H
2
S
in
rat
models
of
non-erosive
esophagitis
.
Mild
-
and
moderate
-severity
non-erosive
esophagitis
was
induced
in
rats
through
supplementation
of
drinking
water
with
fructose
,
plus
or
minus
exposure
to
water-immersion
stress
.
The
effects
of
inhibitors
of
H
2
S
synthesis
or
of
an
H
2
S
donor
on
severity
of
esophagitis
was
then
examined
,
along
with
changes
in
serum
levels
of
a
pro-
and
an
anti-
inflammatory
cytokine
(
IL
-
17
and
IL
-
10
,
respectively
)
.
Exposure
to
water-immersion
stress
after
consumption
of
the
fructose-supplemented
water
for
28
days
resulted
in
submucosal
esophageal
edema
and
neutrophil
infiltration
and
the
development
of
lesions
in
the
muscular
lamina
and
basal
cell
hyperplasia
.
Inhibition
of
H
2
S
synthesis
resulted
in
significant
exacerbation
of
inflammation
and
injury
.
Serum
levels
of
IL
-
17
were
significantly
elevated
,
while
serum
IL
-
10
levels
were
reduced
.
Treatment
with
an
H
2
S
donor
significantly
reduced
the
severity
of
esophageal
injury
and
inflammation
and
normalized
the
serum
cytokine
levels
.
The
rat
models
used
in
this
study
provide
novel
tools
for
studying
non-erosive
esophagitis
with
a
range
of
severity
.
H
2
S
contributes
significantly
to
mucosal
defence
in
the
esophagus
,
and
H
2
S
donors
may
have
therapeutic
value
in
treating
esophageal
inflammation
and
injury
.
Diseases
Validation
Diseases presenting
"edema"
symptom
acute rheumatic fever
adrenomyeloneuropathy
aniridia
cadasil
canavan disease
classical phenylketonuria
coats disease
congenital toxoplasmosis
cushing syndrome
cutaneous mastocytosis
erythropoietic protoporphyria
esophageal carcinoma
fabry disease
familial mediterranean fever
focal myositis
harlequin ichthyosis
homocystinuria without methylmalonic aciduria
inclusion body myositis
lamellar ichthyosis
liposarcoma
lymphangioleiomyomatosis
malignant atrophic papulosis
pleomorphic liposarcoma
systemic capillary leak syndrome
trochlear dysplasia
von hippel-lindau disease
waldenström macroglobulinemia
This symptom has already been validated