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Prognostic Significance of MicroRNA-375 Downregulation in Solid Tumors: A Meta-Analysis.
[esophageal carcinoma]
Objective
.
Recently
,
many
studies
have
shown
that
microRNAs
(
miRNA
)
exhibit
altered
expression
in
various
cancers
and
may
play
an
important
role
as
prognostic
biomarker
of
cancers
.
We
performed
a
meta
-analysis
to
evaluate
the
impact
of
miR-
375
expression
in
solid
tumors
on
patients
'
overall
survival
(
OS
)
.
Methods
.
Studies
were
identified
by
searching
PubMed
,
Embace
,
and
Cochrane
Library
(
last
search
update
was
in
May
2014
)
and
were
assessed
by
further
quality
evaluation
.
The
pooled
hazard
ratios
(
HRs
)
with
95
%
confidence
intervals
(
CIs
)
for
total
and
stratified
analyses
were
calculated
to
investigate
the
association
between
miR-
375
expression
and
cancer
patients
OS
.
Results
.
Our
analysis
results
indicated
that
downregulation
of
miR-
375
predicted
poor
OS
(
HR
=
1
.
91
,
95
%
CI
1
.
48
-
2
.
45
,
P
<
0
.
001
)
.
Subgroup
analyses
showed
that
lower
expression
of
miR-
375
was
significantly
related
with
poor
OS
in
patients
with
esophageal
carcinoma
(
HR
=
2
.
24
,
95
%
CI
1
.
69
-
2
.
96
,
P
<
0
.
001
)
and
non-
small
-cell
lung
cancer
(
NSCLC
)
(
HR
=
1
.
71
,
95
%
CI
1
.
31
-
2
.
24
,
P
<
0
.
001
)
.
Conclusions
.
The
findings
from
this
meta
-analysis
suggest
that
miR-
375
expression
is
associated
with
OS
of
patients
with
malignant
tumors
and
could
be
a
useful
clinical
prognostic
biomarker
.
Diseases
Validation
Diseases presenting
"could be a useful clinical prognostic biomarker"
symptom
esophageal carcinoma
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