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Prognostic value of preoperative platelet-lymphocyte and neutrophil-lymphocyte ratio in patients undergoing surgery for esophageal squamous cell cancer.
[esophageal carcinoma]
Increasing
evidence
has
suggested
that
the
host
inflammatory
status
is
associated
with
prognosis
of
several
solid
tumors
.
Preoperative
platelet
-lymphocyte
ratio
(
PLR
)
and
neutrophil-lymphocyte
ratio
(
NLR
)
,
both
acquired
from
routine
blood
tests
,
can
reflect
the
status
of
systematic
inflammation
.
However
,
whether
they
are
correlated
with
clinical
outcomes
of
esophageal
carcinoma
is
still
unknown
.
The
purpose
of
this
study
was
to
determine
the
prognostic
value
of
preoperative
PLR
and
NLR
in
patients
with
resected
esophageal
squamous
cell
carcinoma
(
ESCC
)
.
Preoperative
PLR
and
NLR
were
evaluated
in
317
eligible
ESCC
patients
from
September
2008
to
December
2010
.
Receiver
operating
characteristic
curves
were
applied
to
establish
optimal
cutoff
points
.
The
prognostic
values
of
PLR
and
NLR
were
determined
by
both
univariate
and
multivariate
analyses
.
The
optimal
cutoff
value
of
preoperative
PLR
and
NLR
were
103
.
0
and
2
.
1
,
respectively
.
One
hundred
and
ninety-
seven
(
62
.
1
%
)
patients
showed
high
level
of
preoperative
PLR
,
while
148
(
46
.
7
%
)
patients
showed
high
level
of
preoperative
NLR
.
Both
elevated
PLR
(
P
<
0
.
001
)
and
NLR
(
P
=
0
.
009
)
were
correlated
with
poor
disease-
specific
survival
in
univariate
analysis
.
However
,
only
preoperative
PLR
(
P
=
0
.
003
)
had
a
significant
correlation
with
prognosis
in
multivariate
analysis
.
In
subgroup
analyses
,
the
predictive
value
of
PLR
was
significant
for
stage
I
(
P
=
0
.
008
)
and
stage
II
(
P
=
0
.
044
)
patients
,
but
not
for
stage
III
patients
(
P
=
0
.
100
)
.
Preoperative
PLR
is
easily
obtained
from
a
routine
blood
test
and
may
provide
additional
prognostic
information
for
ESCC
patients
,
especially
in
the
early
stage
.
Diseases
Validation
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"early stage"
symptom
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