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Clinicopathological and prognostic significance of epidermal growth factor receptor overexpression in patients with esophageal adenocarcinoma: a meta-analysis.
[esophageal adenocarcinoma]
The
prognostic
significance
of
epidermal
growth
factor
receptor
(
EGFR
)
overexpression
in
patients
with
esophageal
adenocarcinoma
(
EAC
)
remains
controversial
.
Eligible
studies
that
investigated
the
association
between
survival
in
EAC
and
the
expression
status
of
EGFR
were
identified
by
an
electronic
search
of
PubMed
,
EMBASE
,
and
ISI
Web
of
Science
.
A
meta
-analysis
was
performed
to
clarify
the
impact
of
EGFR
overexpression
on
clinicopathological
parameters
or
overall
survival
(
OS
)
in
EAC
.
A
total
of
seven
studies
including
1028
patients
were
subjected
to
the
final
analysis
.
The
overall
results
suggested
that
overexpression
of
EGFR
was
significantly
correlated
with
not
only
the
depth
of
invasion
,
lymph
node
status
,
and
tumors
stage
of
EAC
,
with
a
pooled
odds
ratio
of
2
.
99
(
95
%
confidence
interval
[
CI
]
:
1
.
07
-
8
.
35
;
Z
=
2
.
09
;
P
=
0
.
037
)
,
3
.
05
(
95
%
CI
:
1
.
77
-
5
.
27
;
Z
=
4
.
00
;
P
<
0
.
001
)
,
and
5
.
37
(
95
%
CI
:
2
.
49
-
11
.
57
;
Z
=
4
.
29
;
P
<
0
.
001
)
,
respectively
,
but
also
the
poorer
OS
with
a
pooled
hazard
ratio
of
2
.
20
(
95
%
CI
:
1
.
47
-
3
.
31
;
Z
=
3
.
79
;
P
<
0
.
001
)
.
Overexpression
of
EGFR
correlates
with
not
only
the
clinicopathological
features
,
but
also
the
worse
OS
,
and
it
might
be
useful
as
a
predictive
biomarker
in
clinical
practice
,
yet
the
clinicopathological
and
prognostic
role
of
EGFR
in
EAC
still
needs
further
confirmation
by
well-designed
prospective
studies
.
Diseases
Validation
Diseases presenting
"growth factor receptor"
symptom
achondroplasia
aromatase deficiency
cholangiocarcinoma
dedifferentiated liposarcoma
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
kallmann syndrome
lymphangioleiomyomatosis
oral submucous fibrosis
proteus syndrome
severe combined immunodeficiency
wiskott-aldrich syndrome
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