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Clinicopathological and prognostic significance of epidermal growth factor receptor overexpression in patients with esophageal adenocarcinoma: a meta-analysis.
[esophageal adenocarcinoma]
The
prognostic
significance
of
epidermal
growth
factor
receptor
(
EGFR
)
overexpression
in
patients
with
esophageal
adenocarcinoma
(
EAC
)
remains
controversial
.
Eligible
studies
that
investigated
the
association
between
survival
in
EAC
and
the
expression
status
of
EGFR
were
identified
by
an
electronic
search
of
PubMed
,
EMBASE
,
and
ISI
Web
of
Science
.
A
meta
-analysis
was
performed
to
clarify
the
impact
of
EGFR
overexpression
on
clinicopathological
parameters
or
overall
survival
(
OS
)
in
EAC
.
A
total
of
seven
studies
including
1028
patients
were
subjected
to
the
final
analysis
.
The
overall
results
suggested
that
overexpression
of
EGFR
was
significantly
correlated
with
not
only
the
depth
of
invasion
,
lymph
node
status
,
and
tumors
stage
of
EAC
,
with
a
pooled
odds
ratio
of
2
.
99
(
95
%
confidence
interval
[
CI
]
:
1
.
07
-
8
.
35
;
Z
=
2
.
09
;
P
=
0
.
037
)
,
3
.
05
(
95
%
CI
:
1
.
77
-
5
.
27
;
Z
=
4
.
00
;
P
<
0
.
001
)
,
and
5
.
37
(
95
%
CI
:
2
.
49
-
11
.
57
;
Z
=
4
.
29
;
P
<
0
.
001
)
,
respectively
,
but
also
the
poorer
OS
with
a
pooled
hazard
ratio
of
2
.
20
(
95
%
CI
:
1
.
47
-
3
.
31
;
Z
=
3
.
79
;
P
<
0
.
001
)
.
Overexpression
of
EGFR
correlates
with
not
only
the
clinicopathological
features
,
but
also
the
worse
OS
,
and
it
might
be
useful
as
a
predictive
biomarker
in
clinical
practice
,
yet
the
clinicopathological
and
prognostic
role
of
EGFR
in
EAC
still
needs
further
confirmation
by
well-designed
prospective
studies
.
Diseases
Validation
Diseases presenting
"well-designed prospective studies"
symptom
esophageal adenocarcinoma
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