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The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells.
[esophageal adenocarcinoma]
MUC
1
is
a
membrane-bound
mucin
known
to
participate
in
tumor
proliferation
.
It
has
been
shown
that
MUC
1
pattern
of
expression
is
modified
during
esophageal
carcinogenesis
,
with
a
progressive
increase
from
metaplasia
to
adenocarcinoma
.
The
principal
cause
of
development
of
esophageal
adenocarcinoma
is
gastro-
esophageal
reflux
and
MUC
1
was
previously
shown
to
be
up-regulated
by
several
bile
acids
present
in
reflux
.
In
this
report
,
our
aim
was
thus
to
determine
whether
MUC
1
plays
a
role
in
biological
properties
of
human
esophageal
cancer
cells
.
For
that
,
a
stable
MUC
1
-
deficient
esophageal
cancer
cell
line
was
established
using
a
shRNA
approach
.
In
vitro
(
proliferation
,
migration
and
invasion
)
and
in
vivo
(
tumor
growth
following
subcutaneous
xenografts
in
SCID
mice
)
biological
properties
of
MUC
1
-
deficient
cells
were
analyzed
.
Our
results
show
that
esophageal
cancer
cells
lacking
MUC
1
were
less
proliferative
and
had
decreased
migration
and
invasion
properties
.
These
alterations
were
accompanied
by
a
decreased
activity
of
NFKB
p
65
,
Akt
and
MAPK
(
p
44
/
42
,
JNK
and
p
38
)
pathways
.
MCM
6
and
TSG
101
tumor
-associated
markers
were
also
decreased
.
Subcutaneous
xenografts
showed
a
significant
decrease
in
tumor
size
when
cells
did
not
express
MUC
1
.
Altogether
,
the
data
indicate
that
MUC
1
plays
a
key
role
in
proliferative
,
migrating
and
invasive
properties
of
esophageal
cancer
cells
as
well
as
in
tumor
growth
promotion
.
MUC
1
mucin
appears
thus
as
a
good
therapeutic
target
to
slow
down
esophageal
tumor
progression
.
Diseases
Validation
Diseases presenting
"tumor growth"
symptom
adrenal incidentaloma
carcinoma of the gallbladder
cholangiocarcinoma
cowden syndrome
cystinuria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
hodgkin lymphoma, classical
liposarcoma
lymphangioleiomyomatosis
primary effusion lymphoma
severe combined immunodeficiency
von hippel-lindau disease
waldenström macroglobulinemia
wiskott-aldrich syndrome
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