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Impact of histone deacetylase 1 and metastasis-associated gene 1 expression in esophageal carcinogenesis.
[esophageal adenocarcinoma]
Animal
models
are
important
for
the
development
of
novel
therapies
for
esophageal
cancer
.
Histone
deacetylase
1
(
HDAC
1
)
/
metastasis-associated
gene
(
MTA
1
)
complexes
inhibit
p
53
acetylation
and
thus
,
inhibit
p
53
-
induced
apoptosis
.
The
aim
of
the
present
study
was
to
evaluate
HDAC
1
and
MTA
1
expression
in
esophageal
carcinogenesis
in
rats
.
The
rats
underwent
a
total
gastrectomy
followed
by
esophagojejunostomy
to
induce
chronic
duodenal
content
reflux
esophagitis
.
The
rats
were
sacrificed
sequentially
at
20
,
30
,
40
and
50
weeks
post-surgery
and
the
esophagi
were
examined
.
Immunohistochemical
analysis
was
conducted
to
assess
the
expression
and
localization
of
HDAC
1
and
MTA
1
.
At
20
weeks
post-surgery
,
squamous
proliferative
hyperplasia
and
Barrett
's
metaplasia
(
BM
)
were
observed
.
While
,
adenocarcinoma-associated
BM
and
squamous
cell
carcinoma
were
observed
at
30
-
50
weeks
post-surgery
.
The
nuclear
expression
of
HDAC
1
and
MTA
1
was
observed
in
all
of
the
stages
of
squamous
carcinogenesis
and
adenocarcinogenesis
,
although
not
in
the
normal
esophageal
epithelium
.
The
expression
of
HDAC
1
and
MTA
1
may
be
involved
in
duodenoesophageal
reflux-induced
neoplastic
transformation
of
the
esophageal
mucosa
into
cancer
cells
with
squamous
and
adeno
differentiation
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
