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Impact of histone deacetylase 1 and metastasis-associated gene 1 expression in esophageal carcinogenesis.
[esophageal adenocarcinoma]
Animal
models
are
important
for
the
development
of
novel
therapies
for
esophageal
cancer
.
Histone
deacetylase
1
(
HDAC
1
)
/
metastasis-associated
gene
(
MTA
1
)
complexes
inhibit
p
53
acetylation
and
thus
,
inhibit
p
53
-
induced
apoptosis
.
The
aim
of
the
present
study
was
to
evaluate
HDAC
1
and
MTA
1
expression
in
esophageal
carcinogenesis
in
rats
.
The
rats
underwent
a
total
gastrectomy
followed
by
esophagojejunostomy
to
induce
chronic
duodenal
content
reflux
esophagitis
.
The
rats
were
sacrificed
sequentially
at
20
,
30
,
40
and
50
weeks
post-surgery
and
the
esophagi
were
examined
.
Immunohistochemical
analysis
was
conducted
to
assess
the
expression
and
localization
of
HDAC
1
and
MTA
1
.
At
20
weeks
post-surgery
,
squamous
proliferative
hyperplasia
and
Barrett
's
metaplasia
(
BM
)
were
observed
.
While
,
adenocarcinoma-associated
BM
and
squamous
cell
carcinoma
were
observed
at
30
-
50
weeks
post-surgery
.
The
nuclear
expression
of
HDAC
1
and
MTA
1
was
observed
in
all
of
the
stages
of
squamous
carcinogenesis
and
adenocarcinogenesis
,
although
not
in
the
normal
esophageal
epithelium
.
The
expression
of
HDAC
1
and
MTA
1
may
be
involved
in
duodenoesophageal
reflux-induced
neoplastic
transformation
of
the
esophageal
mucosa
into
cancer
cells
with
squamous
and
adeno
differentiation
.