Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Lifetime risk of esophageal adenocarcinoma in patients with Barrett's esophagus.
[esophageal adenocarcinoma]
To
investigate
the
lifetime
risk
of
development
of
esophageal
adenocarcinoma
and
/
or
high
-grade
dysplasia
in
patients
diagnosed
with
Barrett
's
esophagus
.
Data
were
extracted
from
the
United
Kingdom
National
Barrett
's
Oesophagus
Registry
on
date
of
diagnosis
,
patient
age
and
gender
of
7877
patients
from
who
had
been
registered
from
35
United
Kingdom
centers
.
Life
expectancy
was
evaluated
from
United
Kingdom
National
Statistics
data
based
upon
gender
and
age
at
year
at
diagnosis
.
These
data
were
then
used
with
published
estimates
of
annual
adenocarcinoma
and
high
-grade
dysplasia
incidences
from
meta
-analyses
and
large
population-based
studies
to
estimate
overall
lifetime
risk
of
development
of
these
study
endpoints
.
The
mean
age
at
diagnosis
of
Barrett
's
esophagus
was
61
.
6
years
in
males
and
67
.
3
years
in
females
.
The
mean
life
expectancy
at
diagnosis
was
23
.
1
years
in
males
,
20
.
7
years
in
females
and
22
.
2
years
overall
.
Using
data
from
published
meta
-analyses
,
the
lifetime
risk
of
development
of
adenocarcinoma
was
between
1
in
8
and
1
in
14
and
the
lifetime
risk
of
high
-grade
dysplasia
or
adenocarcinoma
was
1
in
5
to
1
in
6
.
Using
data
from
3
large
recent
population-based
cohort
studies
the
lifetime
risk
of
adenocarcinoma
was
between
1
in
10
and
1
in
37
and
of
the
combined
end-point
of
high
-grade
dysplasia
and
adenocarcinoma
was
between
1
in
8
and
1
in
20
.
Age
at
Barrett
's
esophagus
diagnosis
is
reducing
and
life
expectancy
is
increasing
,
which
will
partially
counter-balance
lower
annual
cancer
incidence
.
There
is
a
significant
lifetime
risk
of
development
of
high
-grade
dysplasia
and
adenocarcinoma
in
Barrett
's
esophagus
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
