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A random Abstract
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Lifetime risk of esophageal adenocarcinoma in patients with Barrett's esophagus.
[esophageal adenocarcinoma]
To
investigate
the
lifetime
risk
of
development
of
esophageal
adenocarcinoma
and
/
or
high
-grade
dysplasia
in
patients
diagnosed
with
Barrett
's
esophagus
.
Data
were
extracted
from
the
United
Kingdom
National
Barrett
's
Oesophagus
Registry
on
date
of
diagnosis
,
patient
age
and
gender
of
7877
patients
from
who
had
been
registered
from
35
United
Kingdom
centers
.
Life
expectancy
was
evaluated
from
United
Kingdom
National
Statistics
data
based
upon
gender
and
age
at
year
at
diagnosis
.
These
data
were
then
used
with
published
estimates
of
annual
adenocarcinoma
and
high
-grade
dysplasia
incidences
from
meta
-analyses
and
large
population-based
studies
to
estimate
overall
lifetime
risk
of
development
of
these
study
endpoints
.
The
mean
age
at
diagnosis
of
Barrett
's
esophagus
was
61
.
6
years
in
males
and
67
.
3
years
in
females
.
The
mean
life
expectancy
at
diagnosis
was
23
.
1
years
in
males
,
20
.
7
years
in
females
and
22
.
2
years
overall
.
Using
data
from
published
meta
-analyses
,
the
lifetime
risk
of
development
of
adenocarcinoma
was
between
1
in
8
and
1
in
14
and
the
lifetime
risk
of
high
-grade
dysplasia
or
adenocarcinoma
was
1
in
5
to
1
in
6
.
Using
data
from
3
large
recent
population-based
cohort
studies
the
lifetime
risk
of
adenocarcinoma
was
between
1
in
10
and
1
in
37
and
of
the
combined
end-point
of
high
-grade
dysplasia
and
adenocarcinoma
was
between
1
in
8
and
1
in
20
.
Age
at
Barrett
's
esophagus
diagnosis
is
reducing
and
life
expectancy
is
increasing
,
which
will
partially
counter-balance
lower
annual
cancer
incidence
.
There
is
a
significant
lifetime
risk
of
development
of
high
-grade
dysplasia
and
adenocarcinoma
in
Barrett
's
esophagus
.
