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Case Report: Detection and quantification of tumor cells in peripheral blood and ascitic fluid from a metastatic esophageal cancer patient using the CellSearch (®) technology.
[esophageal adenocarcinoma]
Analysis
of
ascitic
fluid
should
help
to
identify
and
characterize
malignant
cells
in
gastrointestinal
cancer
.
However
,
despite
a
high
specificity
,
the
sensitivity
of
traditional
ascitic
fluid
cytology
remains
insufficient
,
at
around
60
%
.
Since
2004
the
CellSearch
(
®
)
technology
has
shown
its
advantages
in
the
detection
of
circulating
tumor
cells
(
CTCs
)
in
peripheral
blood
,
which
can
perform
an
accurate
diagnosis
and
molecular
analysis
at
the
same
time
.
To
our
knowledge
,
no
previous
study
has
explored
the
potential
utility
of
this
technology
for
the
detection
and
quantification
of
tumor
cells
in
ascitic
fluid
samples
.
Herein
we
report
a
case
of
metastatic
esophageal
adenocarcinoma
in
a
70
-
year
-old
man
presenting
with
dysphagia
and
a
large
amount
of
fluid
in
the
peritoneal
cavity
.
Analysis
of
a
peripheral
blood
sample
and
ascites
sample
with
the
CellSearch
(
®
)
technology
both
revealed
the
presence
of
putative
tumor
cells
that
were
positive
for
epithelial
cell
adhesion
molecule
(
EpCAM
)
and
cytokeratin
(
CK
)
expression
.
This
study
confirmed
the
hematogenous
dissemination
of
esophageal
cancer
by
the
detection
of
circulating
tumor
cells
in
the
peripheral
blood
,
and
is
the
first
to
demonstrate
that
tumor
cells
can
be
identified
in
ascitic
fluid
by
using
CellSearch
(
®
)
technology
.
Diseases
Validation
Diseases presenting
"dysphagia"
symptom
alexander disease
cadasil
cushing syndrome
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
inclusion body myositis
kindler syndrome
liposarcoma
locked-in syndrome
neuralgic amyotrophy
oligodontia
triple a syndrome
well-differentiated liposarcoma
This symptom has already been validated