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Case Report: Detection and quantification of tumor cells in peripheral blood and ascitic fluid from a metastatic esophageal cancer patient using the CellSearch (®) technology.
[esophageal adenocarcinoma]
Analysis
of
ascitic
fluid
should
help
to
identify
and
characterize
malignant
cells
in
gastrointestinal
cancer
.
However
,
despite
a
high
specificity
,
the
sensitivity
of
traditional
ascitic
fluid
cytology
remains
insufficient
,
at
around
60
%
.
Since
2004
the
CellSearch
(
®
)
technology
has
shown
its
advantages
in
the
detection
of
circulating
tumor
cells
(
CTCs
)
in
peripheral
blood
,
which
can
perform
an
accurate
diagnosis
and
molecular
analysis
at
the
same
time
.
To
our
knowledge
,
no
previous
study
has
explored
the
potential
utility
of
this
technology
for
the
detection
and
quantification
of
tumor
cells
in
ascitic
fluid
samples
.
Herein
we
report
a
case
of
metastatic
esophageal
adenocarcinoma
in
a
70
-
year
-old
man
presenting
with
dysphagia
and
a
large
amount
of
fluid
in
the
peritoneal
cavity
.
Analysis
of
a
peripheral
blood
sample
and
ascites
sample
with
the
CellSearch
(
®
)
technology
both
revealed
the
presence
of
putative
tumor
cells
that
were
positive
for
epithelial
cell
adhesion
molecule
(
EpCAM
)
and
cytokeratin
(
CK
)
expression
.
This
study
confirmed
the
hematogenous
dissemination
of
esophageal
cancer
by
the
detection
of
circulating
tumor
cells
in
the
peripheral
blood
,
and
is
the
first
to
demonstrate
that
tumor
cells
can
be
identified
in
ascitic
fluid
by
using
CellSearch
(
®
)
technology
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated