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Case Report: Detection and quantification of tumor cells in peripheral blood and ascitic fluid from a metastatic esophageal cancer patient using the CellSearch (®) technology.
[esophageal adenocarcinoma]
Analysis
of
ascitic
fluid
should
help
to
identify
and
characterize
malignant
cells
in
gastrointestinal
cancer
.
However
,
despite
a
high
specificity
,
the
sensitivity
of
traditional
ascitic
fluid
cytology
remains
insufficient
,
at
around
60
%
.
Since
2004
the
CellSearch
(
®
)
technology
has
shown
its
advantages
in
the
detection
of
circulating
tumor
cells
(
CTCs
)
in
peripheral
blood
,
which
can
perform
an
accurate
diagnosis
and
molecular
analysis
at
the
same
time
.
To
our
knowledge
,
no
previous
study
has
explored
the
potential
utility
of
this
technology
for
the
detection
and
quantification
of
tumor
cells
in
ascitic
fluid
samples
.
Herein
we
report
a
case
of
metastatic
esophageal
adenocarcinoma
in
a
70
-
year
-old
man
presenting
with
dysphagia
and
a
large
amount
of
fluid
in
the
peritoneal
cavity
.
Analysis
of
a
peripheral
blood
sample
and
ascites
sample
with
the
CellSearch
(
®
)
technology
both
revealed
the
presence
of
putative
tumor
cells
that
were
positive
for
epithelial
cell
adhesion
molecule
(
EpCAM
)
and
cytokeratin
(
CK
)
expression
.
This
study
confirmed
the
hematogenous
dissemination
of
esophageal
cancer
by
the
detection
of
circulating
tumor
cells
in
the
peripheral
blood
,
and
is
the
first
to
demonstrate
that
tumor
cells
can
be
identified
in
ascitic
fluid
by
using
CellSearch
(
®
)
technology
.
Diseases
Validation
Diseases presenting
"tumor cells in the peripheral blood"
symptom
esophageal adenocarcinoma
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