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The effect of laparoscopic fundoplication in therapy of Barrett's esophagus.
[esophageal adenocarcinoma]
Barrett
's
esophagus
is
the
most
significant
precancer
of
the
esophagus
.
Its
malignization
gives
rise
to
most
adenocarcinomas
of
the
esophagus
.
Therefore
selection
of
adequate
therapy
for
this
precancerous
condition
is
of
the
utmost
importance
.
The
authors
of
the
work
addressed
the
question
of
whether
effective
therapy
of
reflux
disease
alone
may
halt
the
process
of
malignization
of
Barrett
's
mucosa
or
even
cause
its
regression
.
The
analyzed
set
comprised
50
patients
with
Barrett
's
esophagus
,
who
in
48
cases
underwent
laparoscopic
fundoplication
and
in
two
cases
underwent
an
indirect
antireflux
procedure
in
the
form
of
gastric
resection
with
a
Roux-en-
Y
gastrojejunal
anastomosis
.
The
effect
of
the
procedure
was
evaluated
by
comparing
preoperative
and
postoperative
endoscopic
examinations
,
as
well
as
histological
analysis
by
biopsy
taken
from
Barrett
's
mucosa
.
In
19
patients
(
38
%
)
,
Barrett
's
mucosa
was
not
detected
postoperatively
.
An
improved
finding
in
terms
of
disappearance
of
mucosal
dysplasia
was
found
in
8
(
16
%
)
patients
.
Findings
remained
unchanged
in
18
(
36
%
)
patients
.
In
5
(
10
%
)
patients
progression
of
the
disease
was
discovered
.
A
surgical
antireflux
procedure
,
primarily
in
the
form
of
laparoscopic
fundoplication
,
is
considered
an
effective
method
for
treating
Barrett
's
esophagus
up
to
the
stage
of
mild
dysplasia
.
If
this
therapy
is
unsuccessful
,
the
method
of
choice
is
local
therapy
,
either
an
endoscopic
mucosectomy
or
radiofrequency
ablation
.
Diseases
Validation
Diseases presenting
"stage of mild dysplasia"
symptom
esophageal adenocarcinoma
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