Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Post-chemoradiation surgical pathology stage can customize the surveillance strategy in patients with esophageal adenocarcinoma.
[esophageal adenocarcinoma]
Current
algorithms
for
surveillance
of
patients
with
esophageal
adenocarcinoma
(
EAC
)
after
chemoradiation
and
surgery
(
trimodality
therapy
[
TMT
]
)
remain
empiric
.
The
authors
hypothesized
that
the
frequency
,
type
,
and
timing
of
relapses
after
TMT
would
be
highly
associated
with
surgical
pathology
stage
(
SPS
)
,
and
therefore
SPS
could
be
used
to
individualize
the
surveillance
strategy
.
Between
2000
and
2010
,
518
patients
with
EAC
were
identified
who
underwent
TMT
at
The
University
of
Texas
MD
Anderson
Cancer
Center
and
were
frequently
surveyed
.
Frequency
,
type
,
and
timing
of
the
first
relapse
(
locoregional
and
/
or
distant
)
were
tabulated
according
to
SPS
.
Standard
statistical
approaches
were
used
.
The
median
follow-up
time
after
esophageal
surgery
was
55
.
4
months
(
range
,
1
.
0
-
149
.
2
months
)
.
Disease
relapse
occurred
in
215
patients
(
41
.
5
%
)
.
Higher
SPS
was
associated
with
a
higher
rate
of
relapse
(
0
/
I
vs
II
/
III
,
P
≤
.
001
;
0
/
I
vs
II
,
P
=
.
002
;
SPS
0
/
I
vs
III
,
P
≤
.
001
;
and
SPS
II
vs
III
,
P
=
.
005
)
and
with
shorter
time
to
relapse
(
P
<
.
001
)
.
Irrespective
of
the
SPS
,
approximately
95
%
of
all
relapses
occurred
within
36
months
of
surgery
.
The
3
-
and
5
-
year
overall
survival
rates
were
shorter
for
patients
with
a
higher
SPS
than
those
with
a
lower
SPS
(
0
/
I
vs
II
/
III
,
P
≤
.
001
;
0
/
I
vs
II
,
P
≤
.
001
;
0
/
I
vs
III
,
P
≤
.
001
;
and
II
vs
III
,
P
=
.
014
)
.
The
compelling
data
show
an
excellent
association
between
SPS
and
frequency
/
type
/
timing
of
relapses
after
TMT
in
patients
with
EAC
.
Thus
,
the
surveillance
strategy
can
potentially
be
customized
based
on
SPS
.
These
data
can
inform
a
future
evidence-based
surveillance
strategy
that
can
be
efficient
and
cost-effective
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated