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Inflammation and Oxidative Stress Markers and Esophageal Adenocarcinoma Incidence in a Barrett's Esophagus Cohort.
[esophageal adenocarcinoma]
Persons
with
Barrett
's
esophagus
experience
increased
risk
of
esophageal
adenocarcinoma
.
Prediagnostic
inflammation
markers
predict
several
cancers
,
but
their
role
in
predicting
esophageal
adenocarcinoma
is
unknown
.
We
investigated
whether
biomarkers
of
inflammation
[
C-
reactive
protein
(
CRP
)
,
interleukin-
6
(
IL
6
)
,
soluble
tumor
necrosis
factor
(
sTNF
)
receptors
I
and
II
]
,
and
of
oxidative
stress
(
F
2
-
isoprostanes
)
predicted
progression
to
esophageal
adenocarcinoma
in
a
prospective
cohort
of
397
patients
with
Barrett
's
esophagus
,
45
of
whom
developed
esophageal
adenocarcinoma
.
Biomarkers
were
measured
in
stored
plasma
samples
from
two
time
points
during
follow-up
,
the
mean
of
which
served
as
the
primary
predictor
.
Adjusted
hazard
ratios
(
HR
)
and
95
%
confidence
intervals
(
CI
)
were
estimated
using
Cox
regression
.
CRP
level
above
the
median
was
associated
with
an
80
%
increased
risk
of
esophageal
adenocarcinoma
.
The
HR
and
95
%
CI
adjusted
for
age
,
gender
,
and
further
adjusted
for
waist-
hip
ratio
and
smoking
were
1
.
98
(
1
.
05
-
3
.
73
)
and
1
.
77
(
0
.
93
-
3
.
37
)
,
respectively
,
with
Ptrend
for
continuous
CRP
=
0
.
04
.
Persons
with
IL
6
levels
above
the
median
also
had
almost
2
-
fold
increased
risk
[
HR
and
95
%
CI
adjusted
for
age
and
gender
,
and
further
adjusted
for
waist-
hip
ratio
and
smoking
were
1
.
95
(
1
.
03
-
3
.
72
)
and
1
.
79
(
0
.
93
-
3
.
43
)
,
respectively
,
but
no
evidence
of
a
trend
was
observed
]
.
Concentrations
of
TNF
receptors
and
F
2
-
isoprostanes
were
not
associated
with
esophageal
adenocarcinoma
risk
.
Further
research
is
needed
to
evaluate
the
role
of
inflammation
and
associated
markers
in
esophageal
adenocarcinoma
development
in
persons
with
Barrett
's
esophagus
.
This
prospective
study
suggests
that
inflammation
markers
,
particularly
CRP
and
IL
6
,
may
help
identify
persons
at
higher
risk
of
progression
to
esophageal
adenocarcinoma
.
Cancer
Epidemiol
Biomarkers
Prev
;
23
(
11
)
;
2393
-
403
.
©
2014
AACR
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated
