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A random Abstract
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Obesity and related risk factors in gastric cardia adenocarcinoma.
[esophageal adenocarcinoma]
Over
recent
decades
,
the
incidence
of
cancers
of
the
gastroesophageal
junction
,
including
gastric
cardia
tumors
,
has
increased
markedly
.
This
is
a
trend
that
has
been
well
documented
,
especially
in
studies
from
the
USA
and
northern
Europe
that
have
also
demonstrated
a
concomitant
rise
in
the
ratio
of
cardia
to
distal
gastric
cancers
.
The
rise
in
the
prevalence
of
gastric
cardia
adenocarcinoma
has
been
paralleled
by
the
worldwide
obesity
epidemic
,
with
almost
all
epidemiological
studies
reporting
increased
body
mass
index
and
obesity
increase
the
risk
of
cardia
cancer
development
.
However
,
the
strength
of
this
association
is
less
marked
than
the
link
between
obesity
and
esophageal
adenocarcinoma
,
and
the
mechanisms
remain
poorly
understood
.
Other
possible
confounders
of
the
relationship
between
obesity
and
cardia
cancer
include
the
decline
in
Helicobacter
pylori
infection
and
the
widespread
use
of
proton
pump
inhibitors
,
although
these
have
rarely
been
controlled
for
in
case-control
and
cohort
studies
investigating
associations
between
obesity
and
cardia
cancer
.
We
review
these
epidemiological
trends
and
discuss
proposed
mechanisms
for
the
association
,
drawing
attention
to
controversies
over
the
difficulty
of
defining
cardia
cancer
.
The
relative
paucity
of
high
-quality
epidemiological
studies
from
other
regions
of
the
world
should
prompt
further
investigation
of
this
issue
,
especially
in
populations
undergoing
rapid
socioeconomic
change
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated