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RING finger proteins are involved in the progression of barrett esophagus to esophageal adenocarcinoma: a preliminary study.
[esophageal adenocarcinoma]
To
investigate
the
differential
expression
of
RING
finger
(
RNF
)
proteins
in
Barrett
esophagus
(
BE
)
and
esophageal
adenocarcinoma
(
EAC
)
.
The
differential
expression
of
RNFs
in
normal
esophagus
(
NE
)
,
BE
,
and
EAC
was
screened
using
microarray
assay
.
Real-time
quantitative
polymerase
chain
reaction
(
PCR
)
,
tissue
micro-array
assay
,
and
Western
blot
analysis
were
independently
performed
to
detect
the
mRNA
and
protein
expression
of
screened
RNFs
.
T
he
expression
of
nine
RNFs
in
the
BE
or
EAC
was
2
-
fold
higher
than
those
in
NE
.
Among
these
proteins
,
the
RNF
32
and
RNF
121
expression
in
BE
was
20
.
3
-
fold
and
16
.
4
-
fold
higher
,
respectively
,
than
that
in
NE
,
and
the
expression
of
RNF
24
,
RNF
130
,
RNF
141
,
RNF
139
,
RNF
11
,
RNF
14
,
and
RNF
159
was
upregulated
more
than
2
-
fold
compared
with
NE
.
The
expression
of
nine
RNFs
was
not
only
upregulated
in
the
EAC
but
was
also
positively
related
to
the
RNF
expression
in
BE
.
The
PCR
results
also
indicated
increased
expression
of
these
RNFs
in
BE
and
EAC
compared
to
NE
.
Furthermore
,
the
mRNA
expression
of
all
RNFs
,
except
for
RNF
141
in
EAC
,
was
dramatically
higher
than
those
in
the
BE
.
Similar
results
were
also
obtained
from
the
Western
blot
analysis
.
A
total
of
nine
RNFs
play
critical
roles
in
the
progression
of
BE
to
EAC
.
Diseases
Validation
Diseases presenting
"increased expression of"
symptom
esophageal adenocarcinoma
focal myositis
homocystinuria without methylmalonic aciduria
omenn syndrome
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