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Body Mass Index and Risk of Second Obesity-Associated Cancers After Colorectal Cancer: A Pooled Analysis of Prospective Cohort Studies.
[esophageal adenocarcinoma]
To
determine
whether
prediagnostic
body
mass
index
(
BMI
)
is
associated
with
risk
of
second
obesity
-associated
cancers
in
colorectal
cancer
(
CRC
)
survivors
,
and
whether
CRC
survivors
have
increased
susceptibility
to
obesity
-associated
cancer
compared
with
cancer
-free
individuals
.
Incident
first
primary
CRC
cases
(
N
=
11
,
598
)
were
identified
from
five
prospective
cohort
studies
.
We
used
Cox
proportional
hazards
regression
models
to
examine
associations
between
baseline
(
prediagnostic
)
BMI
and
risk
of
second
obesity
-associated
cancers
(
postmenopausal
breast
,
kidney
,
pancreas
,
esophageal
adenocarcinoma
,
endometrium
)
in
CRC
survivors
,
and
compared
associations
to
those
for
first
obesity
-associated
cancers
in
the
full
cohort
.
Compared
with
survivors
with
normal
prediagnostic
BMI
(
18
.
5
-
24
.
9
kg
/
m
(
2
)
)
,
those
who
were
overweight
(
25
-
29
.
9
kg
/
m
(
2
)
)
or
obese
(
30
+
kg
/
m
(
2
)
)
had
greater
risk
of
a
second
obesity
-associated
cancer
(
n
=
224
;
overweight
hazard
ratio
[
HR
]
,
1
.
39
;
95
%
CI
,
1
.
01
to
1
.
92
;
obese
HR
,
1
.
47
;
95
%
CI
,
1
.
02
to
2
.
12
;
per
5
-
unit
change
in
BMI
HR
,
1
.
12
;
95
%
CI
,
0
.
98
to
1
.
29
)
.
The
magnitude
of
risk
for
developing
a
first
primary
obesity
-associated
cancer
was
similar
(
overweight
HR
,
1
.
18
;
95
%
CI
,
1
.
14
to
1
.
21
;
obese
HR
,
1
.
61
;
95
%
CI
,
1
.
56
to
1
.
66
;
per
5
-
unit
change
in
BMI
HR
,
1
.
23
;
95
%
CI
,
1
.
21
to
1
.
24
)
.
Before
diagnosis
CRC
patients
were
somewhat
more
likely
than
the
overall
cohort
to
be
overweight
(
44
%
v
41
%
)
or
obese
(
25
%
v
21
%
)
.
CRC
survivors
who
were
overweight
or
obese
before
diagnosis
had
increased
risk
of
second
obesity
-associated
cancers
compared
with
survivors
with
normal
weight
.
The
risks
were
similar
in
magnitude
to
those
observed
for
first
cancers
in
this
population
,
suggesting
increased
prevalence
of
overweight
or
obesity
,
rather
than
increased
susceptibility
,
may
contribute
to
elevated
second
cancer
risks
in
colorectal
cancer
survivors
compared
with
the
general
population
.
These
results
support
emphasis
of
existing
weight
guidelines
for
this
high
-risk
group
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated