Association between glutathione S-transferases P1 Ile105Val polymorphism and susceptibility to esophageal cancer: evidence from 20 case-control studies.

[esophageal adenocarcinoma]

Available epidemiological studies had estimated the correlation between glutathione S-transferases P 1 (GSTP 1 ) Ile 105 V al polymorphism and esophageal cancer (EC ) risk . However , the conclusions were controversial and inconclusive . An updated meta -analysis was conducted to explore whether GSTP 1 polymorphism could be contributed to the EC risk . Ultimately , a total of 2 ,992 cases and 4 ,758 controls from 20 previous studies were included . Crude odds ratios (ORs ) with 95 Â % confidence intervals (95 Â % CIs ) were used to assess the strength of the associations . Pooled results suggested that GSTP 1 Ile 105 V al polymorphism significantly increased the risk of developing EC in Caucasians under three genetic models (G vs . A , OR 1 .146 , 95 Â % CI 1 .031 -1 .275 , P Â =Â 0 .012 , I (2 )Â =Â 30 .40 Â %; GA vs . AA , OR 1 .208 , 95 Â % CI 1 .036 -1 .408 , P Â =Â 0 .016 , I (2 )Â =Â 50 .30 Â %; GG +GA vs . AA , OR 1 .219 , 95 Â % CI 1 .053 -1 .410 , P Â =Â 0 .008 , I (2 )Â =Â 44 .50 Â %). However , no significant correlation was found in Asians , African and mixed ethnicities analyses . Moreover , similar results were detected for any genetic model in esophageal squamous cell carcinoma and esophageal adenocarcinoma when stratifying for pathologic types . This meta -analysis provides new evidences that GSTP 1 Ile 105 Val gene polymorphism contributes to EC susceptibility in Caucasians .

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Diseases presenting "mixed ethnicities analyses" symptom

esophageal adenocarcinoma

esophageal squamous cell carcinoma

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