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Alcohol Consumption and the Neoplastic Progression in Barrett's Esophagus: A Systematic Review and Meta-Analysis.
[esophageal adenocarcinoma]
In
the
developed
countries
,
the
incidence
of
esophageal
adenocarcinoma
(
EAC
)
is
increasing
over
recent
decades
.
The
purpose
of
this
meta
-analysis
was
to
arrive
at
quantitative
conclusions
about
the
contribution
of
alcohol
intakes
and
the
progression
of
Barrett
's
esophagus
.
A
comprehensive
,
systematic
bibliographic
search
of
medical
literature
published
up
to
Oct
2013
was
conducted
to
identify
relevant
studies
.
A
meta
-analysis
was
conducted
for
alcohol
consumption
on
the
Barrett
's
esophagus
progression
.
A
total
of
882
cases
in
6
,
867
individuals
from
14
observational
studies
were
indemnified
in
this
meta
-analysis
.
The
result
of
this
current
meta
-analysis
,
including
10
case-control
and
4
cohort
studies
,
indicated
that
alcohol
consumption
was
not
associated
with
the
neoplastic
progression
in
Barrett
's
esophagus
(
RR
,
1
.
17
;
95
%
CI
,
0
.
93
-
1
.
48
)
.
When
stratified
by
the
study
designs
,
no
significant
association
was
detected
in
either
high
vs
low
group
or
ever
vs
never
group
.
Alcohol
drinking
is
not
associated
with
risk
of
neoplastic
progression
in
Barrett
's
esophagus
.
Further
well
designed
studies
are
needed
in
this
area
.
