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A random Abstract
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SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma.
[esophageal adenocarcinoma]
Gastric
cancer
is
the
second
most
common
cause
of
cancer
-related
death
worldwide
,
and
the
incidence
of
esophageal
adenocarcinoma
is
rising
.
While
some
progress
has
been
made
in
treatment
strategies
,
overall
survival
remains
very
poor
for
patients
with
adenocarcinoma
in
the
upper
gastrointestinal
tract
.
Special
AT-rich
sequence
binding
protein
1
(
SATB
1
)
is
a
global
genome
organizer
that
has
been
demonstrated
to
promote
aggressive
tumor
behavior
in
several
different
types
of
cancer
,
including
gastric
cancer
.
The
prognostic
value
of
SATB
1
expression
in
esophageal
cancer
has
,
however
,
not
yet
been
described
.
In
this
study
,
expression
of
SATB
1
was
examined
by
immunohistochemistry
on
tissue
microarrays
prepared
from
tissue
samples
from
175
patients
with
adenocarcinoma
of
the
esophagus
,
cardia
,
or
stomach
and
containing
normal
tissue
,
intestinal
metaplasia
,
primary
tumors
,
and
metastases
.
A
well-validated
antibody
was
used
.
We
found
SATB
1
to
be
an
independent
prognostic
factor
in
patients
with
a
radically
resected
tumor
,
correlating
with
shorter
overall
survival
as
well
as
with
shorter
recurrence-free
survival
.
SATB
1
expression
was
also
found
to
be
significantly
lower
in
primary
tumors
associated
with
intestinal
metaplasia
than
those
without
intestinal
metaplasia
.
This
observation
is
of
potential
biological
interest
as
it
has
been
proposed
that
intestinal
metaplasia-associated
tumors
constitute
a
less
aggressive
phenotype
.
Diseases
Validation
Diseases presenting
"cancer-related"
symptom
cowden syndrome
cushing syndrome
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
neuralgic amyotrophy
primary effusion lymphoma
systemic capillary leak syndrome
thoracic outlet syndrome
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