Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma.
[esophageal adenocarcinoma]
Gastric
cancer
is
the
second
most
common
cause
of
cancer
-related
death
worldwide
,
and
the
incidence
of
esophageal
adenocarcinoma
is
rising
.
While
some
progress
has
been
made
in
treatment
strategies
,
overall
survival
remains
very
poor
for
patients
with
adenocarcinoma
in
the
upper
gastrointestinal
tract
.
Special
AT-rich
sequence
binding
protein
1
(
SATB
1
)
is
a
global
genome
organizer
that
has
been
demonstrated
to
promote
aggressive
tumor
behavior
in
several
different
types
of
cancer
,
including
gastric
cancer
.
The
prognostic
value
of
SATB
1
expression
in
esophageal
cancer
has
,
however
,
not
yet
been
described
.
In
this
study
,
expression
of
SATB
1
was
examined
by
immunohistochemistry
on
tissue
microarrays
prepared
from
tissue
samples
from
175
patients
with
adenocarcinoma
of
the
esophagus
,
cardia
,
or
stomach
and
containing
normal
tissue
,
intestinal
metaplasia
,
primary
tumors
,
and
metastases
.
A
well-validated
antibody
was
used
.
We
found
SATB
1
to
be
an
independent
prognostic
factor
in
patients
with
a
radically
resected
tumor
,
correlating
with
shorter
overall
survival
as
well
as
with
shorter
recurrence-free
survival
.
SATB
1
expression
was
also
found
to
be
significantly
lower
in
primary
tumors
associated
with
intestinal
metaplasia
than
those
without
intestinal
metaplasia
.
This
observation
is
of
potential
biological
interest
as
it
has
been
proposed
that
intestinal
metaplasia-associated
tumors
constitute
a
less
aggressive
phenotype
.
Diseases
Validation
Diseases presenting
"cancer"
symptom
achondroplasia
acute rheumatic fever
adrenal incidentaloma
alpha-thalassemia
benign recurrent intrahepatic cholestasis
cadasil
canavan disease
carcinoma of the gallbladder
cholangiocarcinoma
coats disease
congenital adrenal hyperplasia
congenital diaphragmatic hernia
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dystrophic epidermolysis bullosa
epidermolysis bullosa simplex
erdheim-chester disease
erythropoietic protoporphyria
esophageal adenocarcinoma
esophageal carcinoma
esophageal squamous cell carcinoma
familial hypocalciuric hypercalcemia
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
inclusion body myositis
junctional epidermolysis bullosa
kabuki syndrome
kallmann syndrome
kindler syndrome
lamellar ichthyosis
liposarcoma
locked-in syndrome
lymphangioleiomyomatosis
monosomy 21
neuralgic amyotrophy
oculocutaneous albinism
oligodontia
oral submucous fibrosis
papillon-lefèvre syndrome
pendred syndrome
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
pyruvate dehydrogenase deficiency
severe combined immunodeficiency
sneddon syndrome
systemic capillary leak syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
This symptom has already been validated