Incidental radiologic findings in the 22q11.2 deletion syndrome.

[22q11.2 deletion syndrome]

The 22 q 11 .2 deletion syndrome is a common genetic microdeletion syndrome that results in cognitive delays and an increased risk of several psychiatric disorders , particularly schizophrenia . The current study investigates the prevalence of incidental neuroradiologic findings within this population and their relationships with psychiatric conditions .Brain MR imaging from 58 individuals with 22 q 11 .2 deletion syndrome was reviewed by board-certified radiologists by using standard clinical procedures . Intracranial incidental findings were classified into 8 categories and compared with a large typically developing cohort .The rate of incidental findings was significantly higher (P < .0001 ) in 22 q 11 .2 deletion syndrome compared with typically developing individuals , driven by a high prevalence of cavum septum pellucidum (19 .0 %) and white matter abnormalities (10 .3 %). Both of these findings were associated with psychosis in 22 q 11 .2 deletion syndrome .Cavum septum pellucidum and white matter hyperintensities are significantly more prevalent in patients with the 22 q 11 .2 deletion syndrome and may represent biomarkers for psychosis .