Photosensitivity in the elderly-think of late-onset protoporphyria.

[erythropoietic protoporphyria]

Photosensitivity is the clinical hallmark of both erythropoietic protoporphyria (EPP ) and X-linked dominant protoporphyria (XLDPP ). Both disorders result from a hereditary dysfunction in heme biosynthesis . Disease onset is usually in early childhood . However , rare patients with late-onset EPP in association with a myeloproliferative disorder or myelodysplastic syndrome have been reported . In this issue , Livideanu et al . describe the first patient with late-onset XLDPP .